ArticleProceedings of the National Academy of Sciences of the United States of America2002
Trehalose accumulation in rice plants confers high tolerance levels to different abiotic stresses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 347 papers, 1 of them a synthesis that pooled it.
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Who cites it
347 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,354 citations in OpenAlex.
- Identification of conserved drought-adaptive genes using a cross-species meta-analysis approach.BMC plant biology · 2015Pooled it
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- Desiccation tolerance mechanisms in the green lineage and beyond.The New phytologist · 2026Review
- Crops exposed to extreme conditions: perspectives of gene editing to improve stress tolerance.Plant cell reports · 2026Review
- Trehalose: a multifunctional sugar and its metabolites are biotechnological targets for crop salinity tolerance under saline conditions.Plant molecular biology · 2026Review
- Adjustment of Respiration Strategies in Roots Contributes to the Waterlogging Resistance inInternational journal of molecular sciences · 2026Article
- Comparative metabolomic and physiological analysis uncovers distinct drought tolerance mechanisms in four rice cultivars.Scientific reports · 2026Article
- Seasonal changes in the physiology and metabolism of grapevine latent buds.Journal of experimental botany · 2026Article
- Pan-genomic analysis and abiotic stress expression of eight TPS gene families in Brassica napus.BMC plant biology · 2026Article
- ScHAL1-Mediated Enhancement of Salt Tolerance in Soybean: From Stable Transgenic Inheritance to Field Trial Validation.Plant biotechnology journal · 2026Article
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Low-NaCl pretreatment promotes seedling growth of Chinese white radish under water deficit via osmotic and energy regulation.BMC plant biology · 2026Article
- Overexpression of theInternational journal of molecular sciences · 2026Article
- Article
- Epigenetic Regulation of Salt Stress Responses in Rice: Mechanisms and Prospects for Enhancing Tolerance.Epigenomes · 2025Review
- Lecanicillium saksenae (Kushwaha) Kurihara and Sukarno, a versatile endophytic entomopathogenic fungus for plant growth promotion in rice (Oryza sativa L.).World journal of microbiology & biotechnology · 2025Article
- Integrated Analyses Reveal the Physiological and Molecular Mechanisms of Brassinolide in Modulating Salt Tolerance in Rice.Plants (Basel, Switzerland) · 2025Article
- Systems analysis of long-term heat stress responses in the C4 grass Setaria viridis.The Plant cell · 2025Article
- Evolution and amplification of the trehalose-6-phosphate synthase gene family in Theaceae.BMC genomics · 2025Article
287 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trehalose is a nonreducing disaccharide of glucose that functions as a compatible solute in the stabilization of biological structures under abiotic stress in bacteria, fungi, and invertebrates. With the notable exception of the desiccation-tolerant "resurrection plants," trehalose is not thought to accumulate to detectable levels in most plants. We report here the regulated overexpression of Escherichia coli trehalose biosynthetic genes (otsA and otsB) as a fusion gene for manipulating abiotic stress tolerance in rice. The fusion gene has the advantages of necessitating only a single transformation event and a higher net catalytic efficiency for trehalose formation. The expression of the transgene was under the control of either tissue-specific or stress-dependent promoters. Compared with nontransgenic rice, several independent transgenic lines exhibited sustained plant growth, less photo-oxidative damage, and more favorable mineral balance under salt, drought, and low-temperature stress conditions. Depending on growth conditions, the transgenic rice plants accumulate trehalose at levels 3-10 times that of the nontransgenic controls. The observation that peak trehalose levels remain well below 1 mgg fresh weight indicates that the primary effect of trehalose is not as a compatible solute. Rather, increased trehalose accumulation correlates with higher soluble carbohydrate levels and an elevated capacity for photosynthesis under both stress and nonstress conditions, consistent with a suggested role in modulating sugar sensing and carbohydrate metabolism. These findings demonstrate the feasibility of engineering rice for increased tolerance of abiotic stress and enhanced productivity through tissue-specific or stress-dependent overproduction of trehalose.
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