ArticleThe Journal of physiology2002
cAMP-independent responses of olfactory neurons in Xenopus laevis tadpoles and their projection onto olfactory bulb neurons.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 36 citations in OpenAlex.
- Distinct interhemispheric connectivity at the level of the olfactory bulb emerges during Xenopus laevis metamorphosis.Cell and tissue research · 2021Article
- Olfaction across the water-air interface in anuran amphibians.Cell and tissue research · 2021Review
- Conservation of Glomerular Organization in the Main Olfactory Bulb of Anuran Larvae.Frontiers in neuroanatomy · 2020Article
- Bimodal processing of olfactory information in an amphibian nose: odor responses segregate into a medial and a lateral stream.Cellular and molecular life sciences : CMLS · 2013Article
- Amino acid- vs. peptide-odorants: responses of individual olfactory receptor neurons in an aquatic species.PloS one · 2012Article
- The styryl dye FM1-43 suppresses odorant responses in a subset of olfactory neurons by blocking cyclic nucleotide-gated (CNG) channels.The Journal of biological chemistry · 2011Article
- Purinergic receptor-mediated Ca signaling in the olfactory bulb and the neurogenic area of the lateral ventricles.Purinergic signalling · 2010Article
- The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Odor coding by modules of coherent mitral/tufted cells in the vertebrate olfactory bulb.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Response profiles to amino acid odorants of olfactory glomeruli in larval Xenopus laevis.The Journal of physiology · 2007Article
- Cannabinoid action in the olfactory epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- In situ background estimation in quantitative fluorescence imaging.Biophysical journal · 2006Article
- Classes and narrowing selectivity of olfactory receptor neurons of Xenopus laevis tadpoles.The Journal of general physiology · 2004Article
- Correlation between olfactory receptor cell type and function in the channel catfish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles.The Journal of physiology · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on responses of olfactory receptor neurons (ORNs) upon application of amino acids and forskolin using a novel slice preparation of the olfactory epithelium of Xenopus laevis tadpoles. Responses were measured using the patch-clamp technique. Both amino acids and forskolin proved to be potent stimuli. Interestingly, a number of ORNs that responded to amino acids did not respond to forskolin. This suggests that some amino acids activate transduction pathways other than the well-known cAMP-mediated one. The differential processing of cAMP-mediated stimuli on the one hand and amino acid stimuli on the other was further elucidated by calcium-imaging of olfactory bulb neurons using a novel nose-olfactory bulb preparation of Xenopus laevis tadpoles. The projection pattern of amino acid-sensitive ORNs to olfactory bulb neurons differed markedly from the projection pattern of forskolin-sensitive ORNs. Olfactory bulb neurons activated by amino acids were located laterally compared to those activated by forskolin, and only a small proportion responded to both stimuli. The ensemble of neurons activated by forskolin was also activated by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the membrane-permeant cAMP analogue 8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate (pCPT-cAMP). We therefore conclude that sensory transduction of a number of amino acids is cAMP independent, and amino acid- and cAMP-mediated responses are processed differentially at the level of the olfactory bulb.
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