Evidence map›Paper›PMID 12456772›Full record

ReviewMolecular pathology : MP2002

Demystified. Nitric oxide.

K Stuart-Smith

Abstract readReview
In one paragraph

Review in Molecular pathology : MP, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Strategies of Pathogens to Escape from NO-Based Host Defense.Antioxidants (Basel, Switzerland) · 2022
    Review
  4. Review
  5. Endothelial dysfunction in injury and inflammation.The American journal of the medical sciences · 2015
    Article
  6. Review
  7. Article
  8. Is nitric oxide a hormone?Iranian biomedical journal · 2011
    Review
  9. Racial differences in nitric oxide-dependent vasorelaxation.Reproductive sciences (Thousand Oaks, Calif.) · 2008
    Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

K Stuart-SmithDepartment of Anaesthesia, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK. stuartk@heartsol.wmids.nhs.uk

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery of nitric oxide (NO) demonstrated that cells could communicate via the manufacture and local diffusion of an unstable lipid soluble molecule. Since the original demonstration of the vascular relaxant properties of endothelium derived NO, this fascinating molecule has been shown to have multiple, complex roles within many biological systems. This review cannot hope to cover all of the recent advances in NO biology, but seeks to place the discovery of NO in its historical context, and show how far our understanding has come in the past 20 years. The role of NO in mitochondrial respiration, and consequently in oxidative stress, is described in detail because these processes probably underline the importance of NO in the development of disease.

Indexed as

AnimalsCell RespirationEndothelium, VascularEvolution, ChemicalHumansMitochondriaNitric OxideOxidative StressSepsisNitric Oxide

Identifiers

PMID12456772
PMCPMC1187271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.