ArticleThe EMBO journal2002
Inverse transposition by the RAG1 and RAG2 proteins: role reversal of donor and target DNA.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins.Molecules (Basel, Switzerland) · 2020Article
- Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity.PloS one · 2009Article
- Target DNA structure plays a critical role in RAG transposition.PLoS biology · 2006Article
- Identification and characterization of a gain-of-function RAG-1 mutant.Molecular and cellular biology · 2006Article
- DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.Molecular and cellular biology · 2004Article
- Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae.Molecular and cellular biology · 2004Article
- V(D)J recombination and the evolution of the adaptive immune system.PLoS biology · 2003Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lymphoid-specific proteins RAG1 and RAG2 initiate V(D)J recombination by introducing DNA double-strand breaks at the recombination signal sequences (RSSs). In addition to DNA cleavage, the versatile RAG1/2 complex is capable of catalyzing several other reactions, including hybrid joint formation and the transposition of signal ends into a second DNA. Here we show that the RAG1/2 complex also mediates an unusual strand transfer reaction, inverse transposition, in which non-RSS DNA is cleaved and subsequently transferred to an RSS sequence by direct transesterification. Characterization of the reaction products and requirements suggests that inverse transposition is related to both hybrid joint formation and signal-end transposition. This aberrant activity provides another possible mechanism for some chromosomal translocations present in lymphoid tumors.
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