ArticleThe EMBO journal2002
XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- The molecular basis of p21-activated kinase-associated neurodevelopmental disorders: From genotype to phenotype.Frontiers in neuroscience · 2023Review
- The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders.Protein & cell · 2022Review
- PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.Cellular oncology (Dordrecht, Netherlands) · 2021Article
- Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex.Cell death and differentiation · 2019Article
- The age-regulated zinc finger factor ZNF367 is a new modulator of neuroblast proliferation during embryonic neurogenesis.Scientific reports · 2018Article
- C8orf46 homolog encodes a novel protein Vexin that is required for neurogenesis in Xenopus laevis.Developmental biology · 2018Article
- PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation.Molecular brain · 2015Article
- Retinoic acid signaling and neuronal differentiation.Cellular and molecular life sciences : CMLS · 2015Review
- Lethality of PAK3 and SGK2 shRNAs to human papillomavirus positive cervical cancer cells is independent of PAK3 and SGK2 knockdown.PloS one · 2015Article
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- Maturin is a novel protein required for differentiation during primary neurogenesis.Developmental biology · 2013Article
- NumbL is essential for Xenopus primary neurogenesis.BMC developmental biology · 2013Article
- PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth.Journal of cell science · 2013Article
- Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.Developmental biology · 2012Article
- p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.Molecular and cellular biology · 2011Article
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- Accelerated evolution of PAK3- and PIM1-like kinase gene families in the zebra finch, Taeniopygia guttata.Molecular biology and evolution · 2010Article
- PAK thread from amoeba to mammals.Journal of cellular biochemistry · 2009Review
- Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated the Xenopus p21-activated kinase 3 (XPak3) by virtue of its expression in the territory of primary neurogenesis in the developing embryo. XPak3, but not the other Pak variants, responds positively to X-Ngnr-1 and negatively to X-Notch-1. A constitutively active form of XPak3, generated by fusing a myristylation signal to the N-terminus (XPak3-myr), induces early cell cycle arrest at high concentrations, while ectopic expression of low amounts induces premature neuronal differentiation. Conversely, XPak3 loss of function achieved by use of an antisense morpholino oligonucleotide increases cell proliferation and inhibits neuronal differentiation; this phenotype is rescued by co-injection of XPak3-myr. We conclude that XPak3 is a novel member of the proneural pathway, functioning downstream of neurogenin to withdraw neuronally programmed cells from the mitotic cell cycle, thus allowing for their differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.