ReviewFrontiers in bioscience : a journal and virtual library2003
Molecular mechanisms of irradiation-induced apoptosis.
Review in Frontiers in bioscience : a journal and virtual library, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Efficacy and mechanism of action of ginsenoside Rg3 on radiation proctitis in rats.Immunity, inflammation and disease · 2024Article
- Article
- Histological analysis of sleep and circadian brain circuitry in cranial radiation-induced hypersomnolence (C-RIH) mouse model.Scientific reports · 2022Article
- Knockdown of Annexin A2 Enhances Radiosensitivity by Increasing G2/M-Phase Arrest, Apoptosis and Activating the p38 MAPK-HSP27 Pathway in Nasopharyngeal Carcinoma.Frontiers in oncology · 2022Article
- Disposal of the large volume of sputum positive forInfection prevention in practice · 2020Article
- Targets for protection and mitigation of radiation injury.Cellular and molecular life sciences : CMLS · 2020Review
- Non-Coding RNAs in Cancer Radiosensitivity: MicroRNAs and lncRNAs as Regulators of Radiation-Induced Signaling Pathways.Cancers · 2020Review
- Biological determinants of radioresistance and their remediation in pancreatic cancer.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-Met.Journal of Cancer · 2017Article
- Ionizing radiation sensitizes breast cancer cells to Bcl-2 inhibitor, ABT-737, through regulating Mcl-1.Radiation research · 2014Article
- The combined effects of irradiation and herpes simplex virus type 1 infection on an immortal gingival cell line.Virology journal · 2014Article
- Increased radiosensitivity and radiation-induced apoptosis in SRC-3 knockout mice.Journal of radiation research · 2014Article
- Association of genetic variants in apoptosis genes FAS and FASL with radiation-induced late toxicity after prostate cancer radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Transcriptome analysis of glioma cells for the dynamic response to γ-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas.Cell death & disease · 2013Article
- The role of cyclin D1 in response to long-term exposure to ionizing radiation.Cell cycle (Georgetown, Tex.) · 2013Review
- Advances and application of radioimmunotherapy in non-Hodgkin lymphoma.American journal of blood research · 2012Article
- Death receptor pathways mediate targeted and non-targeted effects of ionizing radiations in breast cancer cells.Carcinogenesis · 2009Article
- Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B.American journal of translational research · 2009Article
- Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine.Radiation research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The following review focuses on our current knowledge as to how the cell death regulatory machinery is activated to mediate irradiation-induced cell death. In particular, we will address recent developments related to the following questions: 1.) Which cell death regulatory genes mediate irradiation-induced cell death? 2.) What is the mechanism of irradiation-induced activation or suppression of cell death regulatory genes (proteins)? 3.) How does the condition of the cell death regulatory machinery affect the cell's sensitivity or resistance to irradiation? Now more than ever, it seems clear that irradiation -induced apoptosis is a complex process involving all three major cell death regulatory pathways: the mitochondria pathway (Bcl-2/Apaf-1), the Iap pathway, and the death receptor pathway. Depending on the cellular context, one or multiple pathways may be activated to mediate irradiation-induced cell death. Therefore, a comprehensive understanding of these processes demands systematic strategies in contrast to traditional approaches that focused on one gene/protein. For this reason, we will also examine recent studies applying genomic (proteomic) methods in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.