ArticleEukaryotic cell2002
Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p is required for efficient induction and execution of meiotic development.
Article in Eukaryotic cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Med13 is required for efficient P-body recruitment and autophagic degradation of Edc3 following nitrogen starvation.Molecular biology of the cell · 2024Article
- Cyclin C-Cdk8 Kinase Phosphorylation of Rim15 Prevents the Aberrant Activation of Stress Response Genes.Frontiers in cell and developmental biology · 2022Article
- Molecular andFrontiers in cell and developmental biology · 2018Review
- Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.Genetics · 2015Article
- Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C.Molecular biology of the cell · 2014Article
- The dual role of cyclin C connects stress regulated gene expression to mitochondrial dynamics.Microbial cell (Graz, Austria) · 2014Review
- Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Acetylation of the transcriptional repressor Ume6p allows efficient promoter release and timely induction of the meiotic transient transcription program in yeast.Molecular and cellular biology · 2014Article
- Stress-induced nuclear-to-cytoplasmic translocation of cyclin C promotes mitochondrial fission in yeast.Developmental cell · 2014Article
- Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast.Cell division · 2013Article
- Global transcriptomic profiling of aspen trees under elevated [CO2] to identify potential molecular mechanisms responsible for enhanced radial growth.Journal of plant research · 2013Article
- Review
- Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence.PloS one · 2011Article
- Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II.Molecular biology of the cell · 2011Article
- The Sin3p PAH domains provide separate functions repressing meiotic gene transcription in Saccharomyces cerevisiae.Eukaryotic cell · 2010Article
- Article
- Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.Genetics · 2009Article
- Meiosis-specific destruction of the Ume6p repressor by the Cdc20-directed APC/C.Molecular cell · 2007Article
- Regulation of the oxidative stress response through Slt2p-dependent destruction of cyclin C in Saccharomyces cerevisiae.Genetics · 2006Article
Corrections and comments
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2 authors at 1 institution in 1 country.
Funding
Abstract
The yeast C-type cyclin Ume3p/Srb11p and its cyclin-dependent kinase partner Ume5p/Srb10p repress the transcription of several genes required for meiotic recombination or meiosis I nuclear division. To relieve this repression, Srbllp is destroyed early in meiosis, prior to the first meiotic division. This report identifies two roles for Srb11p in regulating meiotic development. First, SRB11 is required for the normal exit from the mitotic cell cycle prior to meiotic induction. Specifically, mutants lacking SRB11 (srb11delta) uncouple bud growth from chromosome segregation, producing small buds with nuclei. The bud growth defect is most likely due to the failure of srb11delta mutants to reestablish polarized actin fibers at the bud tip following exposure to sporulation medium. Second, Srb11p is required for the efficient execution of meiosis I. srb11delta mutants either exhibited a delay in performing meiosis I and meiosis II or skipped meiosis I entirely. This meiotic defect is not due to the activation of the recombination or spindle assembly checkpoint pathways. However, the expression of several meiotic genes is delayed and reduced in the mutant strains. These results suggest a positive role for Srb10-Srb11p in regulating the transcription program. This model is supported by the finding that overexpression of the meiotic inducer IME2 partially restored the ability of srb11 mutants to perform meiosis I. In conclusion, these findings indicate that Srb11p is required for both entry into and execution of the meiotic program, thus describing multiple roles for a C-type cyclin in the regulation of a developmental pathway.
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