ArticleEukaryotic cell2002
Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae.
Article in Eukaryotic cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Assembly and phosphoregulatory mechanisms of the budding yeast outer kinetochore KMN complex.The Journal of cell biology · 2026Article
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- The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms.Communications biology · 2025Article
- A role for β-1,6- and β-1,3-glucans in kinetochore function in Saccharomyces cerevisiae.Genetics · 2024Article
- Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochore stability in yeast.Genetics · 2023Article
- Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.Nature communications · 2021Article
- Article
- Outer kinetochore protein Dam1 promotes centromere clustering in parallel with Slk19 in budding yeast.Chromosoma · 2019Article
- Network of protein interactions within the Drosophila inner kinetochore.Open biology · 2016Article
- Why are essential genes essential? - The essentiality ofMicrobial cell (Graz, Austria) · 2015Review
- Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore.Molecular biology reports · 2014Article
- Review
- Identification of highly synchronized subnetworks from gene expression data.BMC bioinformatics · 2013Article
- Cdc14-dependent dephosphorylation of a kinetochore protein prior to anaphase in Saccharomyces cerevisiae.Genetics · 2010Article
- Molecular architecture and assembly of the yeast kinetochore MIND complex.The Journal of cell biology · 2010Article
- Article
- In vivo protein architecture of the eukaryotic kinetochore with nanometer scale accuracy.Current biology : CB · 2009Article
- The evolutionary conserved BER1 gene is involved in microtubule stability in yeast.Current genetics · 2008Article
- The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Molecular biology of the cell · 2007Article
- Molecular architecture of a kinetochore-microtubule attachment site.Nature cell biology · 2006Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Previously, antibodies were raised against a nuclear envelope-enriched fraction of yeast, and the essential gene NNF1 was cloned by reverse genetics. Here it is shown that the conditional nnf1-17 mutant has decreased stability of a minichromosome in addition to mitotic spindle defects. I have identified the novel essential genes DSN1, DSN3, and NSL1 through genetic interactions with nnf1-17. Dsn3p was found to be equivalent to the kinetochore protein Mtw1p. By indirect immunofluorescence, all four proteins, Nnf1p, Mtw1p, Dsn1p, and Nsl1p, colocalize and are found in the region of the spindle poles. Based on the colocalization of these four proteins, the minichromosome instability and the spindle defects seen in nnf1 mutants, I propose that Nnf1p is part of a new group of proteins necessary for chromosome segregation.
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