ArticleEukaryotic cell2002
Myosin I is required for hypha formation in Candida albicans.
Article in Eukaryotic cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
- Myosin-II proteins are involved in the growth, morphogenesis, and virulence of the human pathogenic fungusFrontiers in cellular and infection microbiology · 2022Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- Article
- Recent advances in understandingF1000Research · 2019Review
- Ras hyperactivation versus overexpression: Lessons from Ras dynamics in Candida albicans.Scientific reports · 2018Article
- A Global Analysis of Kinase Function inFrontiers in cellular and infection microbiology · 2018Article
- A class-II myosin is required for growth, conidiation, cell wall integrity and pathogenicity of Magnaporthe oryzae.Virulence · 2017Article
- Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis.Scientific reports · 2017Article
- Myosin 1b functions as an effector of EphB signaling to control cell repulsion.The Journal of cell biology · 2015Article
- Regulation and control of myosin-I by the motor and light chain-binding domains.Trends in cell biology · 2013Review
- Motor protein Myo5p is required to maintain the regulatory circuit controlling WOR1 expression in Candida albicans.Eukaryotic cell · 2012Article
- Actin organization and dynamics in filamentous fungi.Nature reviews. Microbiology · 2011Review
- Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans.Antimicrobial agents and chemotherapy · 2011Article
- Growth of Candida albicans hyphae.Nature reviews. Microbiology · 2011Review
- The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways.Medical mycology · 2011Review
- The fungal type II myosin in Penicillium marneffei, MyoB, is essential for chitin deposition at nascent septation sites but not actin localization.Eukaryotic cell · 2011Article
- Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p.BMC microbiology · 2010Article
- Candida albicans SH3-domain proteins involved in hyphal growth, cytokinesis, and vacuolar morphology.Current genetics · 2010Article
- Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans.Molecular microbiology · 2010Article
- Initial polarized bud growth by endocytic recycling in the absence of actin cable-dependent vesicle transport in yeast.Molecular biology of the cell · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenic yeast Candida albicans can undergo a dramatic change in morphology from round yeast cells to long filamentous cells called hyphae. We have cloned the CaMYO5 gene encoding the only myosin I in C. albicans. A strain with a deletion of both copies of CaMYO5 is viable but cannot form hyphae under all hypha-inducing conditions tested. This mutant exhibits a higher frequency of random budding and a depolarized distribution of cortical actin patches relative to the wild-type strain. We found that polar budding, polarized localization of cortical actin patches, and hypha formation are dependent on a specific phosphorylation site on myosin I, called the "TEDS-rule" site. Mutation of this serine 366 to alanine gives rise to the null mutant phenotype, while a S366D mutation, the product of which mimics a phosphorylated serine, allows hypha formation. However, the S366D mutation still causes a depolarized distribution of cortical actin patches in budding cells, similar to that in the null mutant. The localization of CaMyo5-GFP together with cortical actin patches at the bud and hyphal tips is also dependent on serine 366. Intriguingly, the cortical actin patches in the majority of the hyphae of the mutant expressing Camyo5(S366D) were depolarized, suggesting that although their distribution is dependent on myosin I localization, polarized cortical actin patches may not be required for hypha formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.