ArticleEukaryotic cell2002
Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene.
Article in Eukaryotic cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Seven-Step Total Synthesis of Conidiogenone B Enabled by Radical Cyclizations.Journal of the American Chemical Society · 2026Article
- Chemical Conversations.Molecules (Basel, Switzerland) · 2025Review
- Production ofPathogens (Basel, Switzerland) · 2023Article
- Strategies for Controlling the Sporulation inJournal of fungi (Basel, Switzerland) · 2022Review
- Review
- Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).Journal of fungi (Basel, Switzerland) · 2022Review
- Diterpene Biosynthesis in Rice Blast FungusFrontiers in fungal biology · 2022Article
- Article
- Synthesis of Cyclohexane-Angularly-Fused Triquinanes.Synthesis · 2021Article
- Marine Terpenoids from Polar Latitudes and Their Potential Applications in Biotechnology.Marine drugs · 2020Review
- Article
- Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.Journal of industrial microbiology & biotechnology · 2017Review
- A Plastic Vegetative Growth Threshold Governs Reproductive Capacity in Aspergillus nidulans.Genetics · 2016Article
- Article
- Molecular and functional evolution of the fungal diterpene synthase genes.BMC microbiology · 2015Article
- The AngFus3 Mitogen-Activated Protein Kinase Controls Hyphal Differentiation and Secondary Metabolism in Aspergillus niger.Eukaryotic cell · 2015Article
- BZcon1, a SANT/Myb-type gene involved in the conidiation of Cochliobolus carbonum.G3 (Bethesda, Md.) · 2014Article
- Reproductive competence: a recurrent logic module in eukaryotic development.Proceedings. Biological sciences · 2013Review
- The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans.Archives of microbiology · 2012Article
- Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum.Applied and environmental microbiology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The filamentous fungus Penicillium cyclopium conidiates in the presence of calcium ions in submerged culture without nutrient limitation according to a precisely timed program. Conidiation could be prematurely induced in a nutritionally sufficient medium which had previously supported growth, suggesting that a metabolite which influenced the process was produced. A diterpenoid with conidiation-inducing activity, conidiogenone, was purified from the culture medium, along with conidiogenol, a putative derivative with delayed activity. Contrary to previous thought, the presence of calcium was demonstrated to only decrease the threshold concentration of conidiogenone required for the induction to proceed. In light of these results, a mechanism of conidiation induction is presented according to which the mycelium produces a conidiation inducer (conidiogenone) that accumulates extracellularly. When a threshold concentration is reached, induction likely takes place by interaction with a specific cellular receptor. The results indicate that conidiogenone is both sufficient and necessary to induce conidiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.