ArticleAmerican journal of human genetics2002
Power and design considerations for a general class of family-based association tests: quantitative traits.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Pooled it
- Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.American journal of human genetics · 2009Pooled it
- Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.American journal of human genetics · 2009Pooled it
- On the analysis of metabolite quantitative trait loci: Impact of different data transformations and study designs.Science advances · 2025Article
- Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.The European respiratory journal · 2023Article
- A family-based study of genetic and epigenetic effects across multiple neurocognitive, motor, social-cognitive and social-behavioral functions.Behavioral and brain functions : BBF · 2022Article
- A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests.Bioinformatics (Oxford, England) · 2021Article
- Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs.Genetic epidemiology · 2021Article
- Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.BMC neuroscience · 2020Article
- Candidate-gene association analysis for a continuous phenotype with a spike at zero using parent-offspring trios.Journal of applied statistics · 2020Article
- metaFARVAT: An Efficient Tool for Meta-Analysis of Family-Based, Case-Control, and Population-Based Rare Variant Association Studies.Frontiers in genetics · 2019Article
- An Adaptive Fisher's Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies.Scientific reports · 2016Article
- Test for association of common variants in GRM7 with alcohol consumption.Alcohol (Fayetteville, N.Y.) · 2016Article
- Family-Based Rare Variant Association Analysis: A Fast and Efficient Method of Multivariate Phenotype Association Analysis.Genetic epidemiology · 2016Article
- MYBPH acts as modifier of cardiac hypertrophy in hypertrophic cardiomyopathy (HCM) patients.Human genetics · 2016Article
- An Analytic Solution to the Computation of Power and Sample Size for Genetic Association Studies under a Pleiotropic Mode of Inheritance.Human heredity · 2016Article
- Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind.Social cognitive and affective neuroscience · 2015Article
- Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families.BMC medical genetics · 2015Article
- Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants.BMC bioinformatics · 2015Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the present article, we address family-based association tests (FBATs) for quantitative traits. We propose an approach to analytical power and sample-size calculations for general FBATs; this approach can be applied to virtually any scenario (missing parental information, multiple offspring per family, etc.). The power calculations are used to discuss optimal choices of the phenotypes for the FBAT statistic and its power's dependence on ascertainment conditions, on study design, and on the correct specification of the distributional assumptions for the phenotypes. We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.