Evidence map›Paper›PMID 12454299›Full record

Trial reportThorax2002

Randomised controlled trial of transcutaneous electrical muscle stimulation of the lower extremities in patients with chronic obstructive pulmonary disease.

G Bourjeily-Habr, C L Rochester, F Palermo, P Snyder, V Mohsenin

Registry-linked trialOpen access · bronzeAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02497144 (Effects of Neuromuscular Electrical Stimulation on Functional Exercise Capacity and Quality of Life in Patients With Interstitial Lung Disease), which is not on this map. Cited by 38 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 9 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02497144 nacompletednot on this mapstarted 2015, after this paper: background citation

Effects of Neuromuscular Electrical Stimulation on Functional Exercise Capacity and Quality of Life in Patients With Interstitial Lung Disease

TypeinterventionalSponsorGazi UniversityRan2015 to 2018Enrolled30ConditionsInterstitial Lung DiseaseArmsNMES Group, Control Group
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 9 syntheses or guidelines pooled it, 206 citations in OpenAlex.

  1. 20 years of neuromuscular electrical stimulation in COPD.European respiratory review : an official journal of the European Respiratory Society · 2024
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  6. Pulmonary rehabilitation for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2015
    Pooled it
  7. Shortness of breath and cough in patients in palliative care.Deutsches Arzteblatt international · 2013
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

G Bourjeily-HabrSection of Pulmonary and Critical Care Medicine, Yale University, New Haven, CT 06520, USA.
C L Rochester
F Palermo
P Snyder
V Mohsenin
Yale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough exercise training improves exercise tolerance in most patients with chronic obstructive pulmonary disease (COPD), some patients with severe disease may not be able to tolerate exercise training due to incapacitating breathlessness. Transcutaneous electrical muscle stimulation (TCEMS) has been shown to improve muscle strength, muscle mass, and performance in paraplegics, patients with knee ligament injury, and patients with peripheral vascular disease. We hypothesised that TCEMS of the lower extremities can improve muscle strength and exercise tolerance in patients with moderate to severe COPD.

methodsA randomised controlled trial of TCEMS of the lower extremities was performed in 18 medically stable patients of mean (SD) age 60.0 (1.5) years with a mean forced expiratory volume in 1 second (FEV(1)) of 1.03 (0.10) l (38% predicted) and residual volume/total lung capacity (RV/TLC) of 59 (2)%. Stimulation of the lower extremities was performed three times a week, 20 minutes each session, for six continuous weeks. Quadriceps and hamstring muscle strength, exercise capacity, and peak oxygen uptake were measured at baseline and after 6 weeks of stimulation.

resultsTCEMS improved both the quadriceps strength (by 39.0 (20.4)% v 9.0 (8.1)%, p=0.046) and hamstring muscle strength (by 33.9 (13.0)% v 2.9 (4.7)%, p=0.038) in the treated (n=9) and sham treated (n=9) groups, respectively. The improvement in muscle strength carried over to better performance in the shuttle walk test in the treated group (36.1% v 1.6% in the treated and sham groups respectively, p=0.007, Mann-Whitney U test). There was no significant change in lung function, peak workload, or peak oxygen consumption in either group. Muscle stimulation was well tolerated by the patients with no dropouts and better than 95% compliance with the protocol.

conclusionsTCEMS of peripheral muscles can be a useful adjunct to the comprehensive pulmonary rehabilitation of patients with COPD.

Indexed as

Double-Blind MethodExercise ToleranceFemaleForced Expiratory VolumeHumansMaleMiddle AgedMuscle, SkeletalPulmonary Disease, Chronic ObstructiveTranscutaneous Electric Nerve StimulationVital CapacityWalking

Identifiers

PMID12454299
PMCPMC1758803
OpenAlexW2170686215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.