ArticleGenetics2002
The gene for the intermediate chain subunit of cytoplasmic dynein is essential in Drosophila.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- The roles of cytoplasmic dynein complex in various ocular disorders.Molecular medicine (Cambridge, Mass.) · 2026Review
- Exploration of the interaction between dynein intermediate chain and dynactin p150Protein science : a publication of the Protein Society · 2025Article
- Hydrogen peroxide initiates oxidative stress and proteomic alterations in meningothelial cells.Scientific reports · 2022Article
- On the genetic basis of the effect of Spiroplasma on the male reproductive fitness of Glossina fuscipes fuscipes.PLoS pathogens · 2022Article
- Understanding the Early Evolutionary Stages of a Tandem Drosophilamelanogaster-Specific Gene Family: A Structural and Functional Population Study.Molecular biology and evolution · 2020Article
- Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.Protein & cell · 2016Article
- The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.Neurogenetics · 2014Article
- The Drosophila MAST kinase Drop out is required to initiate membrane compartmentalisation during cellularisation and regulates dynein-based transport.Development (Cambridge, England) · 2014Article
- Functional relevance of the newly evolved sperm dynein intermediate chain multigene family in Drosophila melanogaster males.Communicative & integrative biology · 2012Article
- Intrinsic disorder in dynein intermediate chain modulates its interactions with NudE and dynactin.The Journal of biological chemistry · 2012Article
- Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila.Molecular biology of the cell · 2012Article
- Functional evidence that a recently evolved Drosophila sperm-specific gene boosts sperm competition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structural dynamics and multiregion interactions in dynein-dynactin recognition.The Journal of biological chemistry · 2011Article
- Article
- Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury.The Journal of cell biology · 2010Article
- Multivalency in the assembly of intrinsically disordered Dynein intermediate chain.The Journal of biological chemistry · 2009Article
- Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation.Molecular biology of the cell · 2008Article
- Motility screen identifies Drosophila IGF-II mRNA-binding protein--zipcode-binding protein acting in oogenesis and synaptogenesis.PLoS genetics · 2008Article
- The functional domain grouping of microtubule associated proteins.Communicative & integrative biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The microtubule motor cytoplasmic dynein powers a variety of intracellular transport events that are essential for cellular and developmental processes. A current hypothesis is that the accessory subunits of the dynein complex are important for the specialization of cytoplasmic dynein function. In a genetic approach to understanding the range of dynein functions and the contribution of the different subunits to dynein motor function and regulation, we have identified mutations in the gene for the cytoplasmic dynein intermediate chain, Dic19C. We used a functional Dic transgene in a genetic screen to recover X-linked lethal mutations that require this transgene for viability. Three Dic mutations were identified and characterized. All three Dic alleles result in larval lethality, demonstrating that the intermediate chain serves an essential function in Drosophila. Like a deficiency that removes Dic19C, the Dic mutations dominantly enhance the rough eye phenotype of Glued(1), a dominant mutation in the gene for the p150 subunit of the dynactin complex, a dynein activator. Additionally, we used complementation analysis to identify an existing mutation, shortwing (sw), as an allele of the dynein intermediate chain gene. Unlike the Dic alleles isolated de novo, shortwing is homozygous viable and exhibits recessive and temperature-sensitive defects in eye and wing development. These phenotypes are rescued by the wild-type Dic transgene, indicating that shortwing is a viable allele of the dynein intermediate chain gene and revealing a novel role for dynein function during wing development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.