ArticleGenetics2002
Regulation of I-transposon activity in Drosophila: evidence for cosuppression of nonhomologous transgenes and possible role of ancestral I-related pericentromeric elements.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- The Role of Transposable Elements in Speciation.Genes · 2018Review
- De novo piRNA cluster formation in the Drosophila germ line triggered by transgenes containing a transcribed transposon fragment.Nucleic acids research · 2013Article
- Regulatory RNAs in the light of Drosophila genomics.Briefings in functional genomics · 2012Review
- Homology-dependent silencing by an exogenous sequence in the Drosophila germline.G3 (Bethesda, Md.) · 2012Article
- The piRNA pathway: a fly's perspective on the guardian of the genome.Trends in genetics : TIG · 2010Review
- An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila.The EMBO journal · 2010Article
- Genomic instability of I elements of Drosophila melanogaster in absence of dysgenic crosses.PloS one · 2010Article
- Population dynamics of PIWI-interacting RNAs (piRNAs) and their targets in Drosophila.Genome research · 2010Article
- Paramutation: the tip of an epigenetic iceberg?Trends in genetics : TIG · 2010Article
- A branching process for the early spread of a transposable element in a diploid population.Journal of mathematical biology · 2008Article
- An epigenetic role for maternally inherited piRNAs in transposon silencing.Science (New York, N.Y.) · 2008Article
- Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation.PLoS genetics · 2007Article
- Natural epigenetic protection against the I-factor, a Drosophila LINE retrotransposon, by remnants of ancestral invasions.PloS one · 2007Article
- Involvement of a short interspersed element in epigenetic transcriptional silencing of the amoebapore gene in Entamoeba histolytica.Eukaryotic cell · 2005Article
- The first steps of transposable elements invasion: parasitic strategy vs. genetic drift.Genetics · 2005Article
- RNA interference: the molecular immune system.Journal of molecular histology · 2004Review
- Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene.Genetics · 2004Article
- Article
- Gene silencing triggered by non-LTR retrotransposons in the female germline of Drosophila melanogaster.Genetics · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that the activity of functional I retrotransposons (I factors) introduced into Drosophila devoid of such elements can be repressed by transgenes containing an internal fragment of the I factor itself and that this repressing effect presents the characteristic features of homology-dependent gene silencing or cosuppression. Here we show that the same transgenes can induce silencing of a nonhomologous reporter gene containing as the sole I-factor sequence its 100-bp promoter fragment. Silencing of the nonhomologous reporter gene shows strong similarities to I-factor cosuppression: It does not require any translation product from the regulating transgenes, sense and antisense constructs are equally potent, and the silencing effect is only maternally transmitted and fully reversible. A search for genomic I-like sequences containing domains with similarities to those of both the regulating and the reporter transgenes led to the identification of four such elements, which therefore could act as intermediates-or relays-in the cosuppression machinery. These results strongly suggest that ancestral transposition-defective I-related elements, which are naturally present in the Drosophila genome, may participate per se in the natural conditions of I-factor silencing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.