ArticleGenetics2002
Estimating the spontaneous mutation rate of loss of sex in the human pathogenic fungus Cryptococcus neoformans.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Roles of Mutation, Ploidy, and Recombination in Adaptive Evolution in Two Divergent Model Yeasts.Genes · 2026Review
- Genetic and Phenotypic Diversities in Experimental Populations of Diploid Inter-Lineage Hybrids in the Human PathogenicMicroorganisms · 2021Article
- Global Sexual Fertility in the Opportunistic PathogenJournal of fungi (Basel, Switzerland) · 2020Article
- Effect of Salt Stress on Mutation and Genetic Architecture for Fitness Components inG3 (Bethesda, Md.) · 2020Article
- Genotypic and Phenotypic Analyses of Two "Isogenic" Strains of the Human Fungal Pathogen Cryptococcus neoformans var. neoformans.Mycopathologia · 2019Article
- Sex and the Imperfect Fungi.Microbiology spectrum · 2017Review
- Fertility depression among cheese-making Penicillium roqueforti strains suggests degeneration during domestication.Evolution; international journal of organic evolution · 2016Article
- Article
- Genomic Correlates of Virulence Attenuation in the Deadly Amphibian Chytrid Fungus, Batrachochytrium dendrobatidis.G3 (Bethesda, Md.) · 2015Article
- Unisexual reproduction.Advances in genetics · 2014Review
- Balancing stability and flexibility within the genome of the pathogen Cryptococcus neoformans.PLoS pathogens · 2013Article
- Asexual reproduction induces a rapid and permanent loss of sexual reproduction capacity in the rice fungal pathogen Magnaporthe oryzae: results of in vitro experimental evolution assays.BMC evolutionary biology · 2012Article
- Is sex necessary?BMC biology · 2011Article
- The evolution of sex: a perspective from the fungal kingdom.Microbiology and molecular biology reviews : MMBR · 2010Review
- Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum.BMC microbiology · 2010Article
- Divergent adaptation promotes reproductive isolation among experimental populations of the filamentous fungus Neurospora.BMC evolutionary biology · 2008Article
- Using the putative asexual fungus Cenococcum geophilum as a model to test how species concepts influence recombination analyses using sequence data from multiple loci.Current genetics · 2007Article
- Multiple losses of sex within a single genus of Microsporidia.BMC evolutionary biology · 2007Article
- The role of pleiotropy in the maintenance of sex in yeast.Genetics · 2007Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few events have evolutionary consequences as pervasive as changes in reproductive behavior. Among those changes, the loss of the ability to undergo sexual reproduction is probably the most profound. However, little is known about the rate of loss of sex. Here I describe an experimental system using the fungus Cryptococcus neoformans and provide the first empirical estimate of the spontaneous mutation rate of loss of sex in fungi. Two critical steps in sexual reproduction in C. neoformans were examined: mating and filamentation. Mating, the fusion of cells of opposite sexes, is a universal first step in eukaryotic sexual reproduction. In contrast, filamentation, a prerequisite process preceding meiosis and sexual spore development, is restricted to C. neoformans and a few other fungal species. After approximately 600 mitotic divisions under favorable asexual growth conditions, mean abilities for mating and filamentation decreased significantly by >67 and 24%, respectively. Similarly, though statistically not significant, the mean vegetative growth rates also decreased and among the mutation accumulation lines, the vegetative growth rates were negatively correlated to the mating ability. The estimated mutation rates to decreases in mating ability and filamentation were in excess of 0.0172 and 0.0036, respectively. The results show that C. neoformans can be a highly attractive model for analyses of reproductive system evolution in fungi.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.