ReviewArthritis research2002
Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome.
Review in Arthritis research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases.Frontiers in immunology · 2022Article
- B cell dysregulation in primary Sjögren's syndrome: A review.The Japanese dental science review · 2019Review
- Primary Sjögren's syndrome: clinical phenotypes, outcome and the development of biomarkers.Immunologic research · 2017Review
- A Potential of sFasL in Preventing Gland Injury in Sjogren's Syndrome.BioMed research international · 2017Article
- Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjögren's syndrome.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Possible Mechanisms of Lymphoma Development in Sjögren's Syndrome.Current immunology reviews · 2013Article
- Incidence of cancer among female patients with systemic lupus erythematosus in Korea.Clinical rheumatology · 2010Article
- Is the blood B-cell subset profile diagnostic for Sjogren syndrome?Annals of the rheumatic diseases · 2009Article
- Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjögren's syndrome and systemic lupus erythematosus.Annals of the rheumatic diseases · 2007Article
- A conspicuous role for B cells In Sjögren's syndrome.Clinical reviews in allergy & immunology · 2007Review
- B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue.Arthritis research & therapy · 2007Review
- [Sjögren's syndrome. Current aspects from a rheumatological point of view].Zeitschrift fur Rheumatologie · 2006Article
- Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody.Arthritis research & therapy · 2005Article
- Recent advances in understanding molecular mechanisms in the pathogenesis and antibody profile of Sjögren's syndrome.Current rheumatology reports · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathologic features and the production of typical autoantibodies. In addition, characteristic changes in the distribution of peripheral B cell subsets and differences in use of immunoglobulin variable-region genes are also features of pSS. Comparison of B cells from the blood and parotid gland of patients with pSS with those of normal donors suggests that there is a depletion of memory B cells from the peripheral blood and an accumulation or retention of these antigen-experienced B cells in the parotids. Because disordered selection leads to considerable differences in the B cell repertoire in these patients, the delineation of its nature should provide important further clues to the pathogenesis of this autoimmune inflammatory disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.