ArticleBMC microbiology2002
The expression, processing and localization of polymorphic membrane proteins in Chlamydia pneumoniae strain CWL029.
Article in BMC microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Epigenetic phase variation in the gut microbiome enhances bacterial adaptation.Cell host & microbe · 2026Article
- Genomic characteristics of emerging human pathogeniScience · 2025Article
- Sequence, structure prediction, and epitope analysis of the polymorphic membrane protein family in Chlamydia trachomatis.PloS one · 2024Article
- Development of Transposon Mutagenesis for Chlamydia muridarum.Journal of bacteriology · 2019Article
- Chlamydial Infection From Outside to Inside.Frontiers in microbiology · 2019Review
- In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine.Biomedical journal · 2018Article
- The Chlamydia pneumoniae Adhesin Pmp21 Forms Oligomers with Adhesive Properties.The Journal of biological chemistry · 2016Article
- Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates.Virulence · 2016Review
- Article
- All subtypes of the Pmp adhesin family are implicated in chlamydial virulence and show species-specific function.MicrobiologyOpen · 2014Article
- The Chlamydia pneumoniae invasin protein Pmp21 recruits the EGF receptor for host cell entry.PLoS pathogens · 2013Article
- Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms.Molecular microbiology · 2011Article
- Members of the Pmp protein family of Chlamydia pneumoniae mediate adhesion to human cells via short repetitive peptide motifs.Molecular microbiology · 2010Article
- Variable expression of surface-exposed polymorphic membrane proteins in in vitro-grown Chlamydia trachomatis.Cellular microbiology · 2010Article
- Comprehensive in silico prediction and analysis of chlamydial outer membrane proteins reflects evolution and life style of the Chlamydiae.BMC genomics · 2009Article
- Chlamydia trachomatis-infected patients display variable antibody profiles against the nine-member polymorphic membrane protein family.Infection and immunity · 2009Article
- Autoprocessing of the Escherichia coli AIDA-I autotransporter: a new mechanism involving acidic residues in the junction region.The Journal of biological chemistry · 2009Article
- The Chlamydia outer membrane protein OmcB is required for adhesion and exhibits biovar-specific differences in glycosaminoglycan binding.Molecular microbiology · 2008Article
- Comparative expression profiling of the Chlamydia trachomatis pmp gene family for clinical and reference strains.PloS one · 2007Article
- Expression, processing, and localization of PmpD of Chlamydia trachomatis Serovar L2 during the chlamydial developmental cycle.PloS one · 2007Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChlamydiae are obligate intracellular bacteria, which are important human pathogens. Genome sequences of C. trachomatis and C. pneumoniae have revealed the presence of a Chlamydia specific gene family encoding polymorphic outer membrane proteins, Pmps. In C. pneumoniae the family comprises twenty-one members, which are all transcribed. In the present study, the expression, processing and localisation of the sixteen full-length Pmps in C. pneumoniae strain CWL029 have been further investigated by two-dimensional gel electrophoresis and immunofluorescence microscopy.
resultsTen Pmps were identified in elementary bodies (EBs). Eight of these were investigated with respect to time dependent expression and all were found to be up-regulated between 36 and 48 hours post infection. Antibodies against Pmp6, 8, 10, 11 and 21 reacted with chlamydiae when infected cells were formalin fixed. Pmp6, Pmp20 and Pmp21 were found in cleaved forms, and the cleavage sites of Pmp6 and Pmp21 were identified.
conclusionsThe Pmps are heavily up-regulated at the time of conversion of RB to EB, and at least ten Pmps are present in EBs. Due to their reaction in formalin fixation it is likely that Pmp6, 8, 10, 11 and 21 are surface exposed. The identified cleavage sites of Pmp6 and Pmp21 are in agreement with the theory that the Pmps are autotransporters.
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