ArticleClinical and experimental immunology2002
Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance.
Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Bacterial and host interactions inFrontiers in microbiology · 2025Review
- Pathophysiology and Evolving Treatment Options of Septic Arthritis: A Narrative Review.Cureus · 2024Review
- Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies.Frontiers in microbiology · 2024Review
- Novel therapeutic interventions towards improved management of septic arthritis.BMC musculoskeletal disorders · 2021Review
- Bacteria and Host Interplay inPathogens (Basel, Switzerland) · 2021Review
- T Cell Immunity and the Quest for Protective Vaccines againstMicroorganisms · 2020Review
- Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice.BMC infectious diseases · 2020Article
- Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome ofFrontiers in immunology · 2018Article
- Article
- Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination.Scientific reports · 2016Article
- Contribution of toll-like receptor 2 to the innate response against Staphylococcus aureus infection in mice.PloS one · 2013Article
- Septic arthritis in the native joint.Current infectious disease reports · 2012Article
- Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in mice.Arthritis research & therapy · 2012Article
- What's New in the Management of Bacterial Septic Arthritis?Current infectious disease reports · 2011Article
- Possible protective role of chloramphenicol in TSST-1 and coagulase-positive Staphylococcus aureus-induced septic arthritis with altered levels of inflammatory mediators.Inflammation · 2011Article
- Pathogenic role of macrophages in intradermal infection of methicillin-resistant Staphylococcus aureus in thermally injured mice.Infection and immunity · 2010Article
- Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae.The American journal of pathology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions. To investigate the role of IL-10 in S. aureus-induced arthritis and sepsis, Balb/c mice, intact or defective with respect to IL-10 gene were intravenously inoculated with bacteria. IL-10-/- mice develop a more frequent and destructive arthritis compared to their congeneic controls. The mechanisms regulating such outcome may be due not only to the anti-inflammatory properties of IL-10 but also, directly or indirectly, to antibacterial features of this molecule. Indeed, inoculation of staphylococci to IL-10-/- mice resulted in higher bacterial load in blood and kidneys compared to congeneic controls. Altogether our data indicate that IL-10 is essential for efficient elimination of bacteria and thereby for protection against septic arthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.