ArticleProceedings of the National Academy of Sciences of the United States of America2002
Penelope retroelements from Drosophila virilis are active after transformation of Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Updated Transposable Element Libraries forbioRxiv : the preprint server for biology · 2026Article
- Experimental evolution reveals hyperparasitic interactions among transposable elements.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Whole genome sequencing in Drosophila virilis identifies Polyphemus, a recently activated Tc1-like transposon with a possible role in hybrid dysgenesis.Mobile DNA · 2014Article
- Article
- What happens when Penelope comes?: An unusual retroelement invades a host species genome exploring different strategies.Mobile genetic elements · 2013Article
- Expression of Drosophila virilis retroelements and role of small RNAs in their intrastrain transposition.PloS one · 2011Article
- Small RNA-based silencing strategies for transposons in the process of invading Drosophila species.RNA (New York, N.Y.) · 2010Article
- Molecular dissection of Penelope transposable element regulatory machinery.Nucleic acids research · 2008Article
- Transcriptome Analysis of ESTs from a Chaetognath Reveals a Deep-Branching Clade of Retrovirus-Like Retrotransposons.The open virology journal · 2008Article
- Effect of divergence time and recombination rate on molecular evolution of Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites.Journal of molecular evolution · 2007Article
- Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains.Genome biology · 2006Article
- Reverse transcriptase and endonuclease activities encoded by Penelope-like retroelements.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Molecular paleontology of transposable elements in the Drosophila melanogaster genome.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The RNA interference system differently responds to the same mobile element in distant Drosophila species.Doklady. Biochemistry and biophysicsArticle
- The retrotransposon Tv1 forms infectious virus-like particles in some lines of Drosophila virilis.Doklady. Biochemistry and biophysicsArticle
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
The Penelope family of retroelements was first described in species of the Drosophila virilis group. Intact elements encode a reverse transcriptase and an endonuclease of the UvrC type, which may play a role in Penelope integration. Penelope is a key element in the induction of D. virilis hybrid dysgenesis, which involves the mobilization of several unrelated families of transposable elements. We here report the successful introduction of Penelope into the germ line of Drosophila melanogaster by P element-mediated transformation with three different constructs. Penelope is actively transcribed in the D. melanogaster genome only in lines transformed with a construct containing a full-length Penelope clone. The transcript is identical to that detected in D. virilis dysgenic hybrids. Most newly transposed Penelope elements have a very complex organization. Significant proliferation of Penelope copy number occurred in some lines during the 24-month period after transformation. The absence of copy number increase with two other constructs suggests that the 5' andor 3' UTRs of Penelope are required for successful transposition in D. melanogaster. No insect retroelement has previously been reported to be actively transcribed and to increase in copy number after interspecific transformation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.