ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Basis of changes in left-right coordination of rhythmic motor activity during development in the rat spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 94 citations in OpenAlex.
- Mapping the Dynamic Recruitment of Spinal Neurons during Fictive Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Single-Cell Reconstruction of Emerging Population Activity in an Entire Developing Circuit.Cell · 2019Article
- Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System.Molecular neurobiology · 2018Article
- Retracing your footsteps: developmental insights to spinal network plasticity following injury.Journal of neurophysiology · 2018Review
- Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.Frontiers in neural circuits · 2017Article
- Spontaneous Network Activity and Synaptic Development.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Serotonergic modulation of post-synaptic inhibition and locomotor alternating pattern in the spinal cord.Frontiers in neural circuits · 2014Review
- Emergence of patterned activity in the developing zebrafish spinal cord.Current biology : CB · 2012Article
- Maturation of the GABAergic transmission in normal and pathologic motoneurons.Neural plasticity · 2011Review
- Functional organization of locomotor interneurons in the ventral lumbar spinal cord of the newborn rat.PloS one · 2011Article
- Genetically defined inhibitory neurons in the mouse spinal cord dorsal horn: a possible source of rhythmic inhibition of motoneurons during fictive locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Early history of glycine receptor biology in Mammalian spinal cord circuits.Frontiers in molecular neuroscience · 2010Article
- Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice.Journal of neurophysiology · 2009Article
- Early postnatal development of reciprocal Ia inhibition in the murine spinal cord.Journal of neurophysiology · 2008Article
- Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis.Brain research reviews · 2008Review
- Gene expression profiling of two distinct neuronal populations in the rodent spinal cord.PloS one · 2008Article
- Segmental, synaptic actions of commissural interneurons in the mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Intrinsic and functional differences among commissural interneurons during fictive locomotion and serotonergic modulation in the neonatal mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basic neuronal networks generating coordinated rhythmic motor activity, such as left-right alternate limb movement during locomotion in mammals, are located in the spinal cord. In rat fetuses, the spatial pattern of the rhythmic activity between the left and right sides is synchronous at and shortly after rhythmogenesis before the pattern becomes alternate by birth. The neuronal mechanisms underlying these developmental changes in the left-right coordination were examined in isolated spinal cord preparations. Calcium imaging of commissural neurons at the early fetal stages revealed that the intracellular Ca2+ concentration of the commissural neurons was elevated by bath-application of 5-hydroxytryptamine (5-HT) in synchrony with the simultaneously recorded rhythmic activity of the ventral root, suggesting that the commissural neurons mediate the left-right coordination of the rhythmic activity from onset of the rhythmogenesis. Using a longitudinal split-bath setup, we show that the synchronicity in pattern of the rhythmic activity is the result of excitatory connections being formed via commissural neurons between the rhythm-generating networks located in the left and right spinal cord. During this period, such connections were found to be mediated by excitatory synaptic transmission via GABA(A) receptors. When the pattern of rhythmic activity became left-right alternate at later fetal stages, these connections, still via GABA(A) receptors, were mediating reciprocal inhibition between the two sides. Nearer birth, glycine receptors took over this role. Our results reveal the nature of the neuronal mechanisms forming the basis of the left-right coordination of rhythmic motor activity during prenatal development.
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12451138PMC6758765W1899226752What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.