ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Glia induce dendritic growth in cultured sympathetic neurons by modulating the balance between bone morphogenetic proteins (BMPs) and BMP antagonists.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
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- Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons.American journal of physiology. Heart and circulatory physiology · 2024Article
- The sympathetic nervous system in development and disease.Nature reviews. Neuroscience · 2021Review
- Collapsin Response Mediator Proteins: Novel Targets for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Review
- Meningeal Bmps Regulate Cortical Layer Formation.Brain plasticity (Amsterdam, Netherlands) · 2018Article
- BMP7 expression in the adult rat brain.IBRO reports · 2017Article
- 9-cis retinoic acid induces neurorepair in stroke brain.Scientific reports · 2017Article
- Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization.Molecular biology of the cell · 2015Article
- REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues.Brain research · 2014Article
- Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Glia determine the course of brain-derived neurotrophic factor-mediated dendritogenesis and provide a soluble inhibitory cue to dendritic growth in the brainstem.Neuroscience · 2012Article
- Inducing dendritic growth in cultured sympathetic neurons.Journal of visualized experiments : JoVE · 2012Article
- Article
- Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress.Journal of neurochemistry · 2009Article
- Essential role of BMPs in FGF-induced secondary lens fiber differentiation.Developmental biology · 2008Article
- Modulation of neuritogenesis by astrocyte muscarinic receptors.The Journal of biological chemistry · 2008Article
- Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development.Neural development · 2008Article
- Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells.Molecular biology of the cell · 2008Article
- Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathway.Developmental biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Dendritic growth in cultured sympathetic neurons requires specific trophic interactions. Previous studies have demonstrated that either coculture with glia or exposure to recombinant bone morphogenetic proteins (BMPs) is both necessary and sufficient to induce dendrite formation. These observations led us to test the hypothesis that BMPs mediate glial-induced dendritic growth. In situ hybridization and immunocytochemical studies indicate that the spatiotemporal expression of BMP5, -6, and -7 in rat superior cervical ganglia (SCG) is consistent with their proposed role in dendritogenesis. In vitro, both SCG glia and neurons were found to express BMP mRNA and protein when grown in the presence or absence of the other cell type. However, addition of ganglionic glia to cultured sympathetic neurons causes a marked increase in BMP proteins coincident with a significant decrease in follistatin and noggin. Functional assays indicate that glial-induced dendritic growth is significantly reduced by BMP7 antibodies and completely inhibited by exogenous noggin and follistatin. These data suggest that glia influence the rapid perinatal expansion of the dendritic arbor in sympathetic neurons by increasing BMP activity via modulation of the balance between BMPs and their antagonists.
Indexed as
Identifiers
12451137PMC6758753W2107010599What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.