ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
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- Genome-scale study of transcription factor expression in the branching mouse lung.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Programming human pluripotent stem cells into white and brown adipocytes.Nature cell biology · 2012Article
- The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.British journal of pharmacology · 2011Review
- Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).Biochimica et biophysica acta · 2011Article
- Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target?Current opinion in investigational drugs (London, England : 2000) · 2010Review
- Characterization of the octamer, a cis-regulatory element that modulates excretory cell gene-expression in Caenorhabditis elegans.BMC molecular biology · 2010Article
- Review
- Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2).British journal of pharmacology · 2005Article
- Organization and expression of the SLC36 cluster of amino acid transporter genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis.Pflugers Archiv : European journal of physiology · 2004Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Despite the importance of myelinating Schwann cells in health and disease, little is known about the genetic mechanisms underlying their development. The POU domain transcription factor pou3f1 (Tst-1, SCIP, Oct-6) is required for the normal differentiation of myelinating Schwann cells, but its precise role requires identification of the genes that it regulates. Here we report the isolation of six genes whose expression is reduced in the absence of pou3f1. Only one of these genes, the fatty acid transport protein P2, was known previously to be expressed in Schwann cells. The LIM domain proteins cysteine-rich protein-1 (CRP1) and CRP2 are expressed in sciatic nerve and induced by forskolin in cultured Schwann cells, but only CRP2 requires pou3f1 for normal expression. pou3f1 appears to require the claw paw gene product for activation of at least some of its downstream effector genes. Expression of the novel Schwann cell genes after nerve injury suggests that they are myelin related. One of the genes, tramdorin1, encodes a novel amino acid transport protein that is localized to paranodes and incisures. Our results suggest that pou3f1 functions to activate gene expression in the differentiation of myelinating Schwann cells.
Indexed as
Identifiers
12451123PMC6758772W1556684753What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.