ArticleMolecular and cellular biology2002
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- SNM1A is crucial for efficient repair of complex DNA breaks in human cells.Nature communications · 2024Article
- Structure and Function of SNM1 Family Nucleases.Advances in experimental medicine and biology · 2023Review
- The SNM1A DNA repair nuclease.DNA repair · 2020Review
- Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink.Nucleic acids research · 2018Article
- Bufalin alters gene expressions associated DNA damage, cell cycle, and apoptosis in human lung cancer NCI-H460 cells in vitro.Molecules (Basel, Switzerland) · 2014Article
- ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells.BMC biology · 2010Article
- SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.The EMBO journal · 2010Article
- RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.The Journal of biological chemistry · 2010Article
- The multifunctional SNM1 gene family: not just nucleases.Future oncology (London, England) · 2010Review
- The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans.The EMBO journal · 2009Article
- SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.Biochemical and biophysical research communications · 2008Article
- The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2.The Journal of biological chemistry · 2008Article
- Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.Oncogene · 2008Article
- Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.DNA repair · 2008Article
- Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection.Journal of virology · 2007Article
- Tying the loose ends together in DNA double strand break repair with 53BP1.Cell division · 2006Article
- 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1.Journal of cancer research and clinical oncology · 2005Article
- Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.Molecular and cellular biology · 2005Article
- Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
snm1 mutants of Saccharomyces cerevisiae have been shown to be specifically sensitive to DNA interstrand crosslinking agents but not sensitive to monofunctional alkylating agents, UV, or ionizing radiation. Five homologs of SNM1 have been identified in the mammalian genome and are termed SNM1, SNM1B, Artemis, ELAC2, and CPSF73. To explore the functional role of human Snm1 in response to DNA damage, we characterized the cellular distribution and dynamics of human Snm1 before and after exposure to DNA-damaging agents. Human Snm1 was found to localize to the cell nucleus in three distinct patterns. A particular cell showed diffuse nuclear staining, multiple nuclear foci, or one or two larger bodies confined to the nucleus. Upon exposure to ionizing radiation or an interstrand crosslinking agent, the number of cells exhibiting Snm1 bodies was reduced, while the population of cells with foci increased dramatically. Indirect immunofluorescence studies also indicated that the human Snm1 protein colocalized with 53BP1 before and after exposure to ionizing radiation, and a physical interaction was confirmed by coimmunoprecipitation assays. Furthermore, human Snm1 foci formed after ionizing radiation were largely coincident with foci formed by human Mre11 and to a lesser extent with those formed by BRCA1, but not with those formed by human Rad51. Finally, we mapped a region of human Snm1 of approximately 220 amino acids that was sufficient for focus formation when attached to a nuclear localization signal. Our results indicate a novel function for human Snm1 in the cellular response to double-strand breaks formed by ionizing radiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.