ArticleMolecular and cellular biology2002
Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 107 citations in OpenAlex.
- The chromatin reader protein MLLT1 is critical to maintain normal B lymphopoiesis.bioRxiv : the preprint server for biology · 2026Article
- The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia.Annals of hematology · 2024Review
- Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas.Cancer cell · 2024Article
- Progression of Notch signaling regulation of B cells under radiation exposure.Frontiers in immunology · 2024Review
- EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity.International journal of hematology · 2023Article
- EBF1 is continuously required for stabilizing local chromatin accessibility in pro-B cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors.Frontiers in immunology · 2022Article
- Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation.Nature communications · 2021Article
- The influence of space and time on the establishment of B cell identity.Biomedical journal · 2019Review
- Expression of PAX-5 in B Cell Hodgkin and Non Hodgkin LymphomaAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming.Genes & development · 2018Article
- EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.PLoS pathogens · 2017Article
- The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia.Blood · 2015Article
- The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.Immunological reviews · 2014Review
- BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.Trends in immunology · 2014Review
- A novel pax5-binding regulatory element in the igκ locus.Frontiers in immunology · 2014Article
- Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes.The Journal of biological chemistry · 2013Article
- The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods.Blood cancer journal · 2013Article
- B cell receptor accessory molecule CD79α: characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias).Fish & shellfish immunology · 2013Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Previous studies have suggested that the early-B-cell-specific mb-1(Igalpha) promoter is regulated by EBF and Pax-5. Here, we used in vivo footprinting assays to detect occupation of binding sites in endogenous mb-1 promoters at various stages of B-cell differentiation. In addition to EBF and Pax-5 binding sites, we detected occupancy of a consensus binding site for E2A proteins (E box) in pre-B cells. EBF and E box sites are crucial for promoter function in transfected pre-B cells, and EBF and E2A proteins synergistically activated the promoter in transfected HeLa cells. Other data suggest that EBF and E box sites are less important for promoter function at later stages of differentiation, whereas binding sites for Pax-5 (and its Ets ternary complex partners) are required for promoter function in all mb-1-expressing cells. Using DNA microarrays, we found that expression of endogenous mb-1 transcripts correlates most closely with EBF expression and negatively with Id1, an inhibitor of E2A protein function, further linking regulation of the mb-1 gene with EBF and E2A. Together, our studies demonstrate the complexity of factors regulating tissue-specific transcription and support the concept that EBF, E2A, and Pax-5 cooperate to activate target genes in early B-cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.