ArticleMolecular and cellular biology2002
Developmental changes in the Sciara II/9A initiation zone for DNA replication.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Finishing the egg.Genetics · 2024Article
- Anatomy and evolution of a DNA replication origin.Chromosoma · 2021Article
- Involvement of G-quadruplex regions in mammalian replication origin activity.Nature communications · 2019Article
- Transcription-dependent regulation of replication dynamics modulates genome stability.Nature structural & molecular biology · 2019Article
- Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication.Nucleic acids research · 2018Article
- A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.Nature communications · 2016Article
- DNA replication origin activation in space and time.Nature reviews. Molecular cell biology · 2015Review
- The hunt for origins of DNA replication in multicellular eukaryotes.F1000prime reports · 2015Review
- Epigenetic landscape for initiation of DNA replication.Chromosoma · 2014Review
- The ecdysone receptor (ScEcR-A) binds DNA puffs at the start of DNA amplification in Sciara coprophila.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Article
- Isolation and characterization of the ecdysone receptor and its heterodimeric partner ultraspiracle through development in Sciara coprophila.Chromosoma · 2013Article
- Regulation of DNA replication during development.Development (Cambridge, England) · 2012Review
- Genome-wide depletion of replication initiation events in highly transcribed regions.Genome research · 2011Article
- Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features.Genome research · 2011Article
- Eukaryotic DNA replication origins: many choices for appropriate answers.Nature reviews. Molecular cell biology · 2010Review
- Isolation of a Drosophila amplification origin developmentally activated by transcription.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Identification of new human origins of DNA replication by an origin-trapping assay.Molecular and cellular biology · 2006Article
- Article
- DNA replication: the unbearable lightness of origins.EMBO reports · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Developmentally regulated initiation of DNA synthesis was studied in the fly Sciara at locus II/9A. PCR analysis of nascent strands revealed an initiation zone that spans approximately 8 kb in mitotic embryonic cells and endoreplicating salivary glands but contracts to 1.2 to 2.0 kb during DNA amplification of DNA puff II/9A. Thus, the amplification origin occurs within the initiation zone used for normal replication. The initiation zone left-hand border is constant, but the right-hand border changes during development. Also, there is a shift in the preferred site for initiation of DNA synthesis during DNA amplification compared to that in preamplification stages. This is the first demonstration that once an initiation zone is defined in embryos, its borders and preferred replication start sites can change during development. Chromatin immunoprecipitation showed that the RNA polymerase II 140-kDa subunit occupies the promoter of gene II/9-1 during DNA amplification, even though intense transcription will not start until the next developmental stage. RNA polymerase II is adjacent to the right-hand border of the initiation zone at DNA amplification but not at preamplification, suggesting that it may influence the position of this border. These findings support a relationship between the transcriptional machinery and establishment of the replication initiation zone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.