ArticleMolecular and cellular biology2002
Differential regulation of E2F1, DP1, and the E2F1/DP1 complex by ARF.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 61 citations in OpenAlex.
- Exploring the Research Progress of Vascular Dementia and Key Regulatory Molecules: E2F1.International journal of molecular sciences · 2026Review
- Dual functionality of MDM2 in PROTACs expands the horizons of targeted protein degradation.Biomarker research · 2025Review
- Bypassing the guardian: regulated cell death pathways in p53-mutant cancers.Cellular & molecular biology letters · 2025Review
- ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss.Molecular cell · 2024Article
- Review
- It's Getting Complicated-A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy.Frontiers in cell and developmental biology · 2022Review
- Post-Translational Regulation of ARF: Perspective in Cancer.Biomolecules · 2020Review
- Post-translational Down-regulation of Melanoma Antigen-A11 (MAGE-A11) by Human p14-ARF Tumor Suppressor.The Journal of biological chemistry · 2015Article
- Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.The Journal of biological chemistry · 2015Article
- Genomic characterization of the mouse ribosomal DNA locus.G3 (Bethesda, Md.) · 2014Article
- Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis.The Journal of biological chemistry · 2013Article
- Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC.Cancer research · 2013Article
- The RIP140 gene is a transcriptional target of E2F1.PloS one · 2012Article
- ARF triggers cell G1 arrest by a P53 independent ERK pathway.Molecular and cellular biochemistry · 2011Article
- Network calisthenics: control of E2F dynamics in cell cycle entry.Cell cycle (Georgetown, Tex.) · 2011Review
- JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1.Cell cycle (Georgetown, Tex.) · 2011Article
- Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions.PLoS genetics · 2010Article
- Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.The Journal of biological chemistry · 2010Article
- ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4.EMBO reports · 2009Article
- Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities.Experimental cell research · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The tumor suppressor protein ARF inhibits MDM2 to activate and stabilize p53. Recent studies provided evidence for p53-independent tumor suppression functions of ARF. For example, it has been shown that ARF induces proteolysis of certain E2F species, including E2F1. In addition, ARF relocalizes E2F1 from the nucleoplasm to nucleolus and inhibits E2F1-activated transcription. Because DP1 is a functional partner of the E2F family of factors, we investigated whether DP1 is also regulated by ARF. Here we show that DP1 associates with ARF. Coexpression of ARF relocalizes DP1 from the cytoplasm to the nucleolus, suggesting that DP1 is also a target of the ARF regulatory pathways. Surprisingly, however, the E2F1/DP1 complex is refractory to ARF regulation. Coexpression of E2F1 and DP1 blocks ARF-induced relocalization of either subunit to the nucleolus. The E2F1/DP1 complex localizes in the nucleoplasm, whereas ARF is detected in the nucleolus, suggesting that ARF does not interact with the E2F1/DP1 complex. Moreover, we show that E2F1 is more stable in the presence of ARF when coexpressed with DP1. These results suggest that ARF differentially regulates the free and heterodimeric forms of E2F1 and DP1. DP1 is a constitutively expressed protein, whereas E2F1 is mainly expressed at the G(1)/S boundary of the cell cycle. Therefore, the E2F1/DP1 complex is abundant only between late G(1) and early S phase. Our results on the differential regulation E2F1, DP1, and the E2F1/DP1 complex suggest the possibility that ARF regulates the function of these cell cycle factors by altering the dynamics of their heterodimerization during progression from G(1) to S phase.
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