ArticleThe Journal of cell biology2002
Iqg1p links spatial and secretion landmarks to polarity and cytokinesis.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A Flow Cytometry-Based Phenotypic Screen To Identify Novel Endocytic Factors inG3 (Bethesda, Md.) · 2018Article
- IQGAP1: insights into the function of a molecular puppeteer.Molecular immunology · 2015Review
- The anillin-related region of Bud4 is the major functional determinant for Bud4's function in septin organization during bud growth and axial bud site selection in budding yeast.Eukaryotic cell · 2015Article
- A molecular rheostat at the interface of cancer and diabetes.Biochimica et biophysica acta · 2013Review
- Exorcising the exocyst complex.Traffic (Copenhagen, Denmark) · 2012Review
- A conserved role of IQGAP1 in regulating TOR complex 1.Journal of cell science · 2012Article
- Cdc42p and Fus2p act together late in yeast cell fusion.Molecular biology of the cell · 2012Article
- IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells.International journal of cell biology · 2012Article
- Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation.The Journal of cell biology · 2011Article
- IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.Bioscience reports · 2011Article
- An emerging role for IQGAP1 in regulating protein traffic.TheScientificWorldJournal · 2010Review
- Inferring a transcriptional regulatory network of the cytokinesis-related genes by network component analysis.BMC systems biology · 2009Article
- IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway.Journal of cell science · 2009Article
- The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.Molecular biology of the cell · 2009Article
- IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B.Molecular and cellular biochemistry · 2008Article
- The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.The Journal of cell biology · 2008Article
- Article
- The yeast actin cytoskeleton: from cellular function to biochemical mechanism.Microbiology and molecular biology reviews : MMBR · 2006Review
- Septin function in yeast model systems and pathogenic fungi.Eukaryotic cell · 2005Review
- Some assembly required: yeast septins provide the instruction manual.Trends in cell biology · 2005Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cytokinesis requires the polarization of the actin cytoskeleton, the secretion machinery, and the correct positioning of the division axis. Budding yeast cells commit to their cytokinesis plane by choosing a bud site and polarizing their growth. Iqg1p (Cyk1p) was previously implicated in cytokinesis (Epp and Chant, 1997; Lippincott and Li, 1998; Osman and Cerione, 1998), as well as in the establishment of polarity and protein trafficking (Osman and Cerione, 1998). To better understand how Iqg1p influences these processes, we performed a two-hybrid screen and identified the spatial landmark Bud4p as a binding partner. Iqg1p can be coimmunoprecipitated with Bud4p, and Bud4p requires Iqg1p for its proper localization. Iqg1p also appears to specify axial bud-site selection and mediates the proper localization of the septin, Cdc12p, as well as binds and helps localize the secretion landmark, Sec3p. The double mutants iqg1Deltasec3Delta and bud4Deltasec3Delta display defects in polarity, budding pattern and cytokinesis, and electron microscopic studies reveal that these cells have aberrant septal deposition. Taken together, these findings suggest that Iqg1p recruits landmark proteins to form a targeting patch that coordinates axial budding with cytokinesis.
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