ArticleJournal of bacteriology2002
Different spectra of stationary-phase mutations in early-arising versus late-arising mutants of Pseudomonas putida: involvement of the DNA repair enzyme MutY and the stationary-phase sigma factor RpoS.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Salmonella stress response systems as targets for anti-virulence strategies.BMC microbiology · 2025Article
- Molecular Evolutionary Dynamics of Energy Limited Microorganisms.Molecular biology and evolution · 2021Article
- Genotoxic Agents Produce Stressor-Specific Spectra of Spectinomycin Resistance Mutations Based on Mechanism of Action and Selection in Bacillus subtilis.Antimicrobial agents and chemotherapy · 2021Article
- Bacterial phenotypic heterogeneity in DNA repair and mutagenesis.Biochemical Society transactions · 2020Review
- Article
- Role of Bacillus subtilis DNA Glycosylase MutM in Counteracting Oxidatively Induced DNA Damage and in Stationary-Phase-Associated Mutagenesis.Journal of bacteriology · 2015Article
- Stress-induced mutation via DNA breaks in Escherichia coli: a molecular mechanism with implications for evolution and medicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Article
- Mutation frequency and spectrum of mutations vary at different chromosomal positions of Pseudomonas putida.PloS one · 2012Article
- Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?Journal of molecular microbiology and biotechnology · 2011Article
- The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli.Molecular microbiology · 2010Article
- Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.Antimicrobial agents and chemotherapy · 2009Article
- Elevated mutation frequency in surviving populations of carbon-starved rpoS-deficient Pseudomonas putida is caused by reduced expression of superoxide dismutase and catalase.Journal of bacteriology · 2009Article
- DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli.Genetics · 2009Article
- Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.PLoS genetics · 2008Article
- Article
- Oxidative DNA damage defense systems in avoidance of stationary-phase mutagenesis in Pseudomonas putida.Journal of bacteriology · 2007Article
- Novel role of mfd: effects on stationary-phase mutagenesis in Bacillus subtilis.Journal of bacteriology · 2006Article
- Article
- Inhibition of mutation and combating the evolution of antibiotic resistance.PLoS biology · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stationary-phase mutations occur in populations of stressed, nongrowing, and slowly growing cells and allow mutant bacteria to overcome growth barriers. Mutational processes in starving cells are different from those occurring in growing bacteria. Here, we present evidence that changes in mutational processes also take place during starvation of bacteria. Our test system for selection of mutants based on creation of functional promoters for the transcriptional activation of the phenol degradation genes pheBA in starving Pseudomonas putida enables us to study base substitutions (C-to-A or G-to-T transversions), deletions, and insertions. We observed changes in the spectrum of promoter-creating mutations during prolonged starvation of Pseudomonas putida on phenol minimal plates. One particular C-to-A transversion was the prevailing mutation in starving cells. However, with increasing time of starvation, the importance of this mutation decreased but the percentage of other types of mutations, such as 2- to 3-bp deletions, increased. The rate of transversions was markedly elevated in the P. putida MutY-defective strain. The occurrence of 2- to 3-bp deletions required the stationary-phase sigma factor RpoS, which indicates that some mutagenic pathway is positively controlled by RpoS in P. putida.
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