ArticleOncogene2002
Differential expression profiling of head and neck squamous carcinoma: significance in their phenotypic and biological classification.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Impact of Secretion-Active Osteoblast-Specific Factor 2 in Promoting Progression and Metastasis of Head and Neck Cancer.Cancers · 2022Article
- Integrated Analysis RevealsFrontiers in oncology · 2020Article
- Expressional analysis of disease-relevant signalling-pathways in primary tumours and metastasis of head and neck cancers.Scientific reports · 2018Article
- New biological markers in the decision of treatment of head and neck cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Review
- Gene expression analysis of SCC tumor cells in muscle tissue.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2012Article
- Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse.BMC cancer · 2009Article
- Searching for molecular markers in head and neck squamous cell carcinomas (HNSCC) by statistical and bioinformatic analysis of larynx-derived SAGE libraries.BMC medical genomics · 2008Article
- Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions.Cancer research · 2008Article
- Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program.International journal of radiation oncology, biology, physics · 2007Article
- Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma.Journal of clinical pathology · 2006Article
- Molecular biology of squamous cell carcinoma of the head and neck.Journal of clinical pathology · 2006Review
- Genomic screening of head and neck cancer and its implications for therapy planning.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2006Review
- Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma.International journal of experimental pathology · 2005Review
- Molecular classification of parathyroid neoplasia by gene expression profiling.The American journal of pathology · 2004Article
- Gene expression screening of salivary gland neoplasms: molecular markers of potential histogenetic and clinical significance.The Journal of molecular diagnostics : JMD · 2004Article
- Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis.Oncogene · 2004Article
- Differential expression profiling of head and neck squamous cell carcinoma (HNSCC).British journal of cancer · 2003Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The genetic events associated with the development and progression of head and neck squamous carcinoma (HNSC) are largely unknown. We analysed 12 matched pairs of histologically normal squamous mucosa and tumor specimens from six conventional and six phenotypic variants HNSC to define the differentially expressed genes in these tumors. Parallel expression analysis of 8055 unique genes was performed, and the level of the hybridization signal for each gene was measured after normalization. Hierarchical cluster analysis of the expressed genes showed distinct inter- and intra-tumoral patterns in and between conventional squamous carcinoma and squamous carcinoma variants. We also identified 26 (0.32%) differentially expressed genes that were consistently different between matched pairs of normal and tumor specimens; a selected set of the overexpressed genes was validated using real-time quantitative RT-PCR. The majority of the genes were associated with differentiation and proliferation. Our study defines a set of genes that could form the basis for the construction of limited HNSC targeted expression array and in-depth studies and further highlights gene profile differences that may be useful in pathobiologic classification of HNSC.
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