ArticleWorld journal of gastroenterology2002
ROC curves in evaluation of serum fibrosis indices for hepatic fibrosis.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers.World journal of gastroenterology · 2006Trial
- Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha.World journal of gastroenterology · 2006Trial
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- Predictive Value of Collagen Biomarkers in Advanced Chronic Kidney Disease Patients.Biomolecules · 2023Article
- Circulating Procollagen Type III N-Terminal Peptide and Physical Function in Adults from the Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Diagnostic Value of Serum Procollagen III N-Terminal Peptide for Liver Fibrosis in Infantile Cholestasis.Frontiers in pediatrics · 2020Article
- Lnc-TCL6 is a potential biomarker for early diagnosis and grade in liver-cirrhosis patients.Gastroenterology report · 2019Article
- Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage.World journal of gastroenterology · 2016Review
- Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis.Scientific reports · 2015Article
- Capillaria hepatica in China.World journal of gastroenterology · 2010Review
- Determination of the relationship of serum hyaluronic Acid levels to the degree of liver fibrosis in biopsies of patients with chronic viral hepatitis B and C.Hepatitis monthly · 2010Article
- Sampling variability of computer-aided fractal-corrected measures of liver fibrosis in needle biopsy specimens.World journal of gastroenterology · 2006Article
- Noninvasive evaluation of hepatic fibrosis in children with infant hepatitis syndrome.World journal of gastroenterology · 2006Article
- Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent.World journal of gastroenterology · 2006Article
- Diagnostic accuracy of serum biochemical fibrosis markers in children with chronic hepatitis B evaluated by receiver operating characteristics analysis.World journal of gastroenterology · 2005Article
- Low plasma apolipoprotein A-I level is not a reliable marker of fibrosis in children with chronic hepatitis B.World journal of gastroenterology · 2004Article
- Relationship between clinical and pathologic findings in patients with chronic liver diseases.World journal of gastroenterology · 2003Article
- Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis.World journal of gastroenterology · 2003Article
- Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters.World journal of gastroenterology · 2003Article
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4 authors.
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Abstract
aimUse Receiver operating characteristic (ROC) curves to find out the relationship between serum level of hyaluronic acid (HA), type III procollagen (PCIII), N-terminal procollagen III peptide (PIIINP), laminin (LN), type IV collagen (C-IV) and hepatic fibrosis, as well as to determine their value in clinical practice.
methods114 serum samples from chronic hepatitis patients were assayed for fibrosis indices including HA, PCIII, PIIINP, LN and IV-C with radioimmunoassay (RIA). Liver biopsy was also performed in all these patients and the biopsy material was examined histopathologically.
resultsROC curves analysis showed that area under the curve (AUC) of PIIINP, HA, PCIII, C-IV and LN was 0.800, 0.728, 0.727, 0.583 and 0.463, respectively. The analysis also showed that PIIINP (r=0.452), HA (r=0.497) and PCIII (r=0.404) have greater diagnosis performances than C-IV(r=0.238) and LN (r=0.128) according to fibrosis staging. The sensitivity of HA plus PIIINP was 55.1 %, it was the most sensitive combination. Combined three or more than three indices that based on HA, the specificity was 100 %. Using combination assays can improve the specificity, but its sensitivity was not high. Serum fibrosis indices increased as the grade of inflammation aggravated. But only PIIINP and PCIII had significant difference between G1 and G2 (PIIINP: 13.16+/-8.07 vs 8.32+/-5.09; PCIII: 164.22+/-65.69 vs 138.23+/-77.63). The coefficient correlation of the results of inflammation grade and fibrosis staging to HA was 0.525 and 0.553 respectively, that to PCIII, 0.446 and 0.412, that to LN, 0.234 and 0.194, and that to IV-C, 0.363 and 0.351, respectively.
conclusionSerum fibrosis indices can indicate tendency of hepatic fibrosis, but it cannot replace liver biopsy. However, as diagnostic markers, more efficient serum fibrosis indices for the diagnosis of hepatic fibrosis need to be explored.
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