ArticleWorld journal of gastroenterology2002
Mast cell density and the context of clinicopathological parameters and expression of p185, estrogen receptor, and proliferating cell nuclear antigen in gastric carcinoma.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- The Role of Mast Cells in Bone Metabolism and Bone Disorders.Frontiers in immunology · 2020Review
- Immune Tumor Microenvironment in Breast Cancer and the Participation of Estrogen and Its Receptors in Cancer Physiopathology.Frontiers in immunology · 2019Review
- Targeting mast cells in gastric cancer with special reference to bone metastases.World journal of gastroenterology · 2015Review
- Any defining role of mast cell or mast cell density in oral squamous cell carcinoma?Annals of medical and health sciences research · 2014Article
- Gender-medicine aspects in allergology.Allergy · 2008Review
- Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx.Molecular immunology · 2007Article
- Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer.World journal of gastroenterology · 2004Article
- Expression of estrogen receptor beta in human colorectal cancer.World journal of gastroenterology · 2004Article
- Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis.World journal of gastroenterology · 2003Article
- Screening and identification of mimotope of gastric cancer associated antigen MGb1-Ag.World journal of gastroenterology · 2003Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between the mast cell density (MCD) and the context of clinicopathological parameters and expression of p185, estrogen receptor (ER), and proliferating cell nuclear antigen (PCNA) in gastric carcinoma.
methodsMast cell, p185, ER, and PCNA were detected using immunohistochemical S-P labeling method. Mast cell was counted in tissue of gastric carcinoma and regional lymph nodes respectively, and involved lymph nodes (ILN) were examined as usual.
resultsMCD was significantly related to both age and depth of penetration (chi(2)=4.688,P<0.05 for age and chi(2)=9.350, P<0.01 for depth of penetration) between MCD>21/0.03 mm(2) and MCD< or =21/0.03 mm(2) in 100 patients; MCD in 1-6 ILN group patients was significantly higher than that in 7-15 ILN or >15 ILN group patients (u=6.881, 8.055, P<0.01); There were significant differences intergroup in positive expression rate of p185, ER and PCNA between MCD>21/0.03 mm(2) and MCD< or =21/0.03 mm(2) in 100 patients.
conclusionMast cell may have effect on inhibiting invasive growth of tumor, especially in the aged patients; The number of mast cells, in certain degree, may predicate the number of involved lymph nodes, which is valuable for assessment of prognosis; MCD was related to the expression of p185, ER, and PCNA in gastric carcinoma. It suggests that mast cell accumulation may inhibit the proliferation and the dissemination of the gastric carcinoma.
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