ArticleWorld journal of gastroenterology2002
Relationship between Egr-1 gene expression and apoptosis in esophageal carcinoma and precancerous lesions.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett's esophagus.Genome medicine · 2021Article
- Relationship between cervical esophageal squamous cell carcinoma and human papilloma virus infection and gene mutations.Molecular and clinical oncology · 2021Article
- Correlations of the expressions of c-Jun and Egr-1 proteins with clinicopathological features and prognosis of patients with nasopharyngeal carcinoma.Cancer biomarkers : section A of Disease markers · 2017Article
- Expression of early growth response gene-1 in precancerous lesions of gastric cancer.Oncology letters · 2016Article
- Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy.Autophagy · 2015Article
- Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice.PloS one · 2011Article
- Effect of local CTLA4Ig gene transfection on acute rejection of small bowel allografts in rats.World journal of gastroenterology · 2004Article
- Expression of Egr-1, c-fos and cyclin D1 in esophageal cancer and its precursors: An immunohistochemical and in situ hybridization study.World journal of gastroenterology · 2004Article
- Early protective effect of ischemic preconditioning on small intestinal graft in rats.World journal of gastroenterology · 2003Article
- Expression of survivin in human gastric carcinoma and gastric carcinoma model of rats.World journal of gastroenterology · 2003Article
- Preoperative TN staging of esophageal cancer: comparison of miniprobe ultrasonography, spiral CT and MRI.World journal of gastroenterology · 2003Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the expression of early growth response gene-1 (Egr-1 gene) and Bcl-X/(L) protein and its relationship with the cell apoptosis in human esophageal carcinoma (EC) and precancerous lesions.
methodsIn situ hybridization(ISH), immunohistochemistry (IHC) and TUNEL method were used respectively to detect Egr-1mRNA, Egr-1 protein, apoptosis related-protein Bcl-X/(L) and cell apoptosis in situ from 66 cases of esophageal squamous cell carcinoma and their upper cut edge and paracancerous mucosa.
resultsEgr-1 gene in situ hybridization, Bcl-X/(L) immunohistochemistry positive products were located in the cytoplasm, while Egr-1 immunohistochemistry and TUNEL positive signal were located in the nuclei. The apoptosis index(AI) and the frequency of apoptosis occurrence were increased gradually from precancerous lesion to cancer (P<0.01) and the expression of Egr-1mRNA and Egr-1 protein in dysplasia was the highest among all specimens (P<0.01). The AI of Egr-1 positive cancer tissues was much higher than that of Egr-1 negative cancer tissues (P<0.01), while the AI of Bcl-X/(L) positive cancer tissues was much lower than that of Bcl-X/(L) negative cancer tissues (P<0.01). The AI and Egr-1 expression were not correlated with invasiveness and lymphatic metastasis in EC.
conclusionCell apoptosis was present through esophageal carcinogenesis. The expression of Egr-1 mRNA and Egr-1 protein were high in precancerous lesion of esophagus. The AI was increased significantly in Egr-1 positive squamous cell carcinoma. Egr-1 might promote apoptotic effect. Egr-1 expression and cell apoptosis may have an important biological significance in esophageal carcinogenesis.
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