ArticleProceedings of the National Academy of Sciences of the United States of America2002
Mitotic chromosomes are chromatin networks without a mechanically contiguous protein scaffold.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 177 citations in OpenAlex.
- Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding.Nature cell biology · 2026Article
- Bridging-mediated compaction of mitotic chromosomes.Nucleus (Austin, Tex.) · 2025Review
- Progressive chromosome shape changes during cell divisions.EMBO reports · 2025Article
- Article
- Independence of centromeric and pericentromeric chromatin stability on CCAN components.Molecular biology of the cell · 2025Article
- Ion-mediated condensation controls the mechanics of mitotic chromosomes.Nature materials · 2024Article
- Ions shaping the mechanics of chromosomes in mitosis.Nature materials · 2024Article
- Cooperative control of a DNA origami force sensor.Scientific reports · 2024Article
- The material properties of mitotic chromosomes.Current opinion in structural biology · 2023Review
- Predicting scale-dependent chromatin polymer properties from systematic coarse-graining.Nature communications · 2023Article
- Structural reorganization and relaxation dynamics of axially stressed chromosomes.Biophysical journal · 2023Article
- Nuclear architecture and the structural basis of mitotic memory.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Direct observation of surface charge and stiffness of human metaphase chromosomes.Nanoscale advances · 2023Article
- Hypothesis: The opposing pulling forces exerted by spindle microtubules can cause sliding of chromatin layers and facilitate sister chromatid resolution.Frontiers in genetics · 2023Article
- Regulation of the mitotic chromosome folding machines.The Biochemical journal · 2022Article
- Article
- Probing the Interaction Between Chromatin and Chromatin-Associated Complexes with Optical Tweezers.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A survey of physical methods for studying nuclear mechanics and mechanobiology.APL bioengineering · 2021Review
- Stochastic chromatin packing of 3D mitotic chromosomes revealed by coherent X-rays.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mitotic chromosomes.Seminars in cell & developmental biology · 2021Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isolated newt (Notophthalmus viridescens) chromosomes were studied by using micromechanical force measurement during nuclease digestion. Micrococcal nuclease and short-recognition-sequence blunt-cutting restriction enzymes first remove the native elastic response of, and then to go on to completely disintegrate, single metaphase newt chromosomes. These experiments rule out the possibility that the mitotic chromosome is based on a mechanically contiguous internal non-DNA (e.g., protein) "scaffold"; instead, the mechanical integrity of the metaphase chromosome is due to chromatin itself. Blunt-cutting restriction enzymes with longer recognition sequences only partially disassemble mitotic chromosomes and indicate that chromatin in metaphase chromosomes is constrained by isolated chromatin-crosslinking elements spaced by approximately 15 kb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.