ArticleProceedings of the National Academy of Sciences of the United States of America2002
Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 97 citations in OpenAlex.
- GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders.Molecular neurobiology · 2025Review
- The GPCR A35 regulates fecundity ofFrontiers in insect science · 2025Article
- FMRFamide-like peptides (FaLPs) - an overview of diverse physiological roles in insects and other arthropods.International journal of biological sciences · 2025Review
- System-wide mapping of peptide-GPCR interactions in C. elegans.Cell reports · 2023Article
- Article
- Nemertean, Brachiopod, and Phoronid Neuropeptidomics Reveals Ancestral Spiralian Signaling Systems.Molecular biology and evolution · 2021Article
- FMRFamide-Related Peptides Signaling Is Involved in the Regulation of Muscle Contractions in Two Tenebrionid Beetles.Frontiers in physiology · 2020Article
- Evolution of neuropeptide signalling systems.The Journal of experimental biology · 2018Review
- An ancient FMRFamide-related peptide-receptor pair induces defence behaviour in a brachiopod larva.Open biology · 2017Article
- Peptidergic control in a fruit crop pest: The spotted-wing drosophila, Drosophila suzukii.PloS one · 2017Article
- FMRFamide signaling promotes stress-induced sleep in Drosophila.Brain, behavior, and immunity · 2015Article
- FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans.PloS one · 2015Article
- Article
- Phylogenetic investigation of Peptide hormone and growth factor receptors in five dipteran genomes.Frontiers in endocrinology · 2013Article
- Article
- Structure-activity studies of RFamide-related peptide-1 identify a functional receptor antagonist and novel cardiac myocyte signaling pathway involved in contractile performance.Journal of medicinal chemistry · 2012Article
- Organically modified silica nanoparticles are biocompatible and can be targeted to neurons in vivo.PloS one · 2012Article
- More than two decades of research on insect neuropeptide GPCRs: an overview.Frontiers in endocrinology · 2012Article
- Select Neuropeptides and their G-Protein Coupled Receptors in Caenorhabditis Elegans and Drosophila Melanogaster.Frontiers in endocrinology · 2012Article
- Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
We here describe the cloning and characterization of the functionally active Drosophila melanogaster (Drm) FMRFamide receptor, which we designated as DrmFMRFa-R. The full-length ORF of a D. melanogaster orphan receptor, CG 2114 (Berkeley Drosophila Genome Project), was cloned from genomic DNA. This receptor is distantly related to mammalian thyroid-stimulating hormone-releasing hormone receptors and to a set of Caenorhabditis elegans orphan receptors. An extract of 5,000 central nervous systems from the related but bigger flesh fly, Neobellieria bullata (Neb), was used to screen cells expressing the orphan receptor. Successive purification steps, followed by MS, revealed the sequence of two previously uncharacterized endogenous peptides, APPQPSDNFIRFamide (Neb-FIRFamide) and pQPSQDFMRFamide (Neb-FMRFamide). These are reminiscent of other insect FMRFamide peptides, having neurohormonal as well as neurotransmitter functions. Nanomolar concentrations of the Drm FMRFamides (DPKQDFMRFamide, TPAEDFMRFamide, SDNFMRFamide, SPKQDFMRFamide, and PDNFMRFamide) activated the cognate receptor in a dose-dependent manner. To our knowledge, the cloned DrmFMRFa-R is the first functionally active FMRFamide G protein-coupled receptor described in invertebrates to date.
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