ArticleThe Journal of clinical investigation2002
Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- 5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects.Lung · 2018Trial
- Identification of multiple public TCR repertoires in chronic beryllium disease.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Reduced CCL/Be-specific CD4+ T cells in CCL3-deficient or peptide-MHCII CAR-T cell-treated mice.JCI insight · 2026Article
- Article
- Protective role of tissue-resident Tregs in a murine model of beryllium-induced disease.JCI insight · 2022Article
- Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation.The Journal of clinical investigation · 2021Article
- Adaptive Immunity in Pulmonary Sarcoidosis and Chronic Beryllium Disease.Frontiers in immunology · 2020Review
- Protective role of B cells in sterile particulate-induced lung injury.JCI insight · 2019Article
- DNA Methylation Changes in Lung Immune Cells Are Associated with Granulomatous Lung Disease.American journal of respiratory cell and molecular biology · 2019Article
- Immunologic Effects of Beryllium Exposure.Annals of the American Thoracic Society · 2018Review
- Interplay of innate and adaptive immunity in metal-induced hypersensitivity.Current opinion in immunology · 2016Review
- Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis.The European respiratory journal · 2016Article
- Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.Mucosal immunology · 2016Article
- MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4⁺ T-cell priming.Mucosal immunology · 2015Article
- p38 Mitogen-Activated Protein Kinase in beryllium-induced dendritic cell activation.Human immunology · 2014Article
- Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.Current opinion in immunology · 2014Review
- Biological exposure metrics of beryllium-exposed dental technicians.Archives of environmental & occupational health · 2014Article
- T cell recognition of beryllium.Current opinion in immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Chronic beryllium disease (CBD) is caused by exposure to beryllium in the workplace, and it remains an important public health concern. Evidence suggests that CD4(+) T cells play a critical role in the development of this disease. Using intracellular cytokine staining, we found that the frequency of beryllium-specific CD4(+) T cells in the lungs (bronchoalveolar lavage) of 12 CBD patients ranged from 1.4% to 29% (mean 17.8%), and these T cells expressed a Th1-type phenotype in response to beryllium sulfate (BeSO(4)). Few, if any, beryllium-specific CD8(+) T cells were identified. In contrast, the frequency of beryllium-responsive CD4(+) T cells in the blood of these subjects ranged from undetectable to 1 in 500. No correlation was observed between the frequency of beryllium-responsive bronchoalveolar lavage (BAL) CD4(+) T cells as detected by intracellular staining and lymphocyte proliferation in culture after BeSO(4) exposure. Staining for surface marker expression showed that nearly all BAL T cells exhibit an effector memory cell phenotype. These results demonstrate a dramatically high frequency and compartmentalization of antigen-specific effector memory CD4(+) cells in the lungs of CBD patients. These studies provide insight into the phenotypic and functional characteristics of antigen-specific T cells invading other inaccessible target organs in human disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.