ArticleThe Journal of clinical investigation2002
The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses.
Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 124 citations in OpenAlex.
- Response ofJournal of bacteriology · 2024Article
- Surface-Shaving ofMicroorganisms · 2024Article
- LinkingAntibiotics (Basel, Switzerland) · 2024Review
- Choosing the right animal model for osteomyelitis research: Considerations and challenges.Journal of orthopaedic translation · 2023Review
- Antimicrobial activity of α-mangostin againstFrontiers in cellular and infection microbiology · 2023Article
- Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome.Molecules (Basel, Switzerland) · 2022Article
- Mechanisms of Antibiotic Failure DuringFrontiers in immunology · 2021Review
- T Cell Immunity and the Quest for Protective Vaccines againstMicroorganisms · 2020Review
- The role of the msaABCR operon in implant-associated chronic osteomyelitis in Staphylococcus aureus USA300 LAC.BMC microbiology · 2020Article
- Quorum Sensing and Toxin Production inToxins · 2020Review
- Staphylococcus aureus Osteomyelitis: Bone, Bugs, and Surgery.Infection and immunity · 2020Review
- WhatsGNU: a tool for identifying proteomic novelty.Genome biology · 2020Article
- Lactobacillus plantarum USM8613 Aids in Wound Healing and Suppresses Staphylococcus aureus Infection at Wound Sites.Probiotics and antimicrobial proteins · 2020Article
- Interaction of host and Staphylococcus aureus protease-system regulates virulence and pathogenicity.Medical microbiology and immunology · 2019Review
- Immunoproteomics to identify Staphylococcus aureus antigens expressed in bovine milk during mastitis.Journal of dairy science · 2018Article
- Targeting fundamental pathways to disrupt Staphylococcus aureus survival: clinical implications of recent discoveries.JCI insight · 2018Review
- Staphylococcus aureus colonization and non-influenza respiratory viruses: Interactions and synergism mechanisms.Virulence · 2018Review
- O-Acetylation of Peptidoglycan Limits Helper T Cell Priming and Permits Staphylococcus aureus Reinfection.Cell host & microbe · 2017Article
- Genomic and transcriptomic comparison between Staphylococcus aureus strains associated with high and low within herd prevalence of intra-mammary infection.BMC microbiology · 2017Article
- Novel Evasion Mechanisms of the Classical Complement Pathway.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Staphylococcus aureus (SA) is an opportunistic pathogen that affects a variety of organ systems and is responsible for many diseases worldwide. SA express an MHC class II analog protein (Map), which may potentiate SA survival by modulating host immunity. We tested this hypothesis in mice by generating Map-deficient SA (Map(-)SA) and comparing disease outcome to wild-type Map(+)SA-infected mice. Map(-)SA-infected mice presented with significantly reduced levels of arthritis, osteomyelitis, and abscess formation compared with control animals. Furthermore, Map(-)SA-infected nude mice developed arthritis and osteomyelitis to a severity similar to Map(+)SA-infected controls, suggesting that T cells can affect disease outcome following SA infection and Map may attenuate cellular immunity against SA. The capacity of Map to alter T cell function was tested more specifically in vitro and in vivo using native and recombinant forms of Map. T cells or mice treated with recombinant Map had reduced T cell proliferative responses and a significantly reduced delayed-type hypersensitivity response to challenge antigen, respectively. These data suggest a role for Map as an immunomodulatory protein that may play a role in persistent SA infections by affecting protective cellular immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.