ArticleThe Journal of experimental medicine2002
Silencing of B cell receptor signals in human naive B cells.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Deoxynivalenol- and zearalenone-contaminated feeds alter gene expression profiles in the livers of piglets.Asian-Australasian journal of animal sciences · 2018Article
- Targeting B Cells and Plasma Cells in Autoimmune Diseases.Frontiers in immunology · 2018Review
- High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.PLoS pathogens · 2009Article
- Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Deciphering CD30 ligand biology and its role in humoral immunity.Immunology · 2006Review
- BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells.Oncogene · 2006Article
- Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease.The Journal of clinical investigation · 2006Article
- Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.The Journal of experimental medicine · 2006Article
- Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells.The Journal of experimental medicine · 2005Article
- Defective B cell responses in the absence of SH2D1A.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells.The Journal of experimental medicine · 2004Article
- Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation.The Journal of experimental medicine · 2003Article
- T lymphoid differentiation in human bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Transcriptional analysis of the B cell germinal center reaction.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
- Retraction · 2006-11-27Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Error in Data · Error in Results and/or Conclusions · Unreliable Data · Unreliable Results and/or Conclusions ·
- RetractedRetraction.2006
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify changes in the regulation of B cell receptor (BCR) signals during the development of human B cells, we generated genome-wide gene expression profiles using the serial analysis of gene expression (SAGE) technique for CD34(+) hematopoietic stem cells (HSCs), pre-B cells, naive, germinal center (GC), and memory B cells. Comparing these SAGE profiles, genes encoding positive regulators of BCR signaling were expressed at consistently lower levels in naive B cells than in all other B cell subsets. Conversely, a large group of inhibitory signaling molecules, mostly belonging to the immunoglobulin superfamily (IgSF), were specifically or predominantly expressed in naive B cells. The quantitative differences observed by SAGE were corroborated by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and flow cytometry. In a functional assay, we show that down-regulation of inhibitory IgSF receptors and increased responsiveness to BCR stimulation in memory as compared with naive B cells at least partly results from interleukin (IL)-4 receptor signaling. Conversely, activation or impairment of the inhibitory IgSF receptor LIRB1 affected BCR-dependent Ca(2+) mobilization only in naive but not memory B cells. Thus, LIRB1 and IL-4 may represent components of two nonoverlapping gene expression programs in naive and memory B cells, respectively: in naive B cells, a large group of inhibitory IgSF receptors can elevate the BCR signaling threshold to prevent these cells from premature activation and clonal expansion before GC-dependent affinity maturation. In memory B cells, facilitated responsiveness upon reencounter of the immunizing antigen may result from amplification of BCR signals at virtually all levels of signal transduction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.