ArticleInfection and immunity2002
Lactoferrin protects rabbits from Shigella flexneri-induced inflammatory enteritis.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00560222 (Randomized, Controlled Trial - Lactoferrin Prevention of Diarrhea in Children), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Controlled Trial - Lactoferrin Prevention of Diarrhea in Children
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Enteral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates.The Cochrane database of systematic reviews · 2019Pooled it
- The Preventive Effect of Lactoferrin-Containing Yogurt on Gastroenteritis in Nursery School Children-Intervention Study for 15 Weeks.International journal of environmental research and public health · 2020Trial
- Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children.The Journal of pediatrics · 2013Trial
- Impact of lactoferrin supplementation on growth and prevalence of Giardia colonization in children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008Trial
- An Oral Inoculation Infant Rabbit Model formBio · 2020Article
- The goat β‑casein/CMV chimeric promoter drives the expression of hLF in transgenic goats produced by cell transgene microinjection.International journal of molecular medicine · 2019Article
- Article
- Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections.International journal of molecular sciences · 2017Review
- Shigella dysenteriae infection activates proinflammatory response through β-catenin/NF-κB signaling pathway.PloS one · 2017Article
- Lactoferrin Enhanced Apoptosis and Protected Against Thioacetamide-Induced Liver Fibrosis in Rats.Open access Macedonian journal of medical sciences · 2015Article
- The Role of Maternal Breast Milk in Preventing Infantile Diarrhea in the Developing World.Current tropical medicine reports · 2014Article
- Effect of lactoferrin on enteric pathogens.Biochimie · 2009Review
- Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2006Review
- In vitro adhesion and invasion inhibition of Shigella dysenteriae, Shigella flexneri and Shigella sonnei clinical strains by human milk proteins.BMC microbiology · 2004Article
- Lactoferrin impairs type III secretory system function in enteropathogenic Escherichia coli.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Shigella species cause bacillary dysentery in humans by invasion, intracellular multiplication, spread to adjacent cells, and induction of brisk inflammatory responses in the intestinal epithelium. In vitro data suggest that lactoferrin, a glycoprotein present in human mucosal secretions, has a role in protection from bacterial enteric infections. We sought to determine the activity of lactoferrin in vivo, using the concentration present in human colostrum, to investigate its effect on the development of clinical and pathological evidence of inflammation in a rabbit model of enteritis. Lactoferrin protected rabbits infected with Shigella flexneri from developing inflammatory intestinal disease. Typical histological changes in ill animals included villous blunting with sloughing of epithelial cells, submucosal edema, infiltration of leukocytes, venous congestion, and hemorrhage. Lactoferrin at a concentration normally found in human colostrum blocks development of S. flexneri-induced inflammatory enteritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.