ArticleInfection and immunity2002
Genomic scale analysis of Pasteurella multocida gene expression during growth within the natural chicken host.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 96 citations in OpenAlex.
- Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice.PLoS pathogens · 2025Article
- Effect of conditioned media from Aeromonas caviae on the transcriptomic changes of the porcine isolates of Pasteurella multocida.BMC microbiology · 2022Article
- Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogenRNA (New York, N.Y.) · 2018Article
- Structure of the bacterial plant-ferredoxin receptor FusA.Nature communications · 2016Article
- The RNA-Binding Chaperone Hfq Is an Important Global Regulator of Gene Expression in Pasteurella multocida and Plays a Crucial Role in Production of a Number of Virulence Factors, Including Hyaluronic Acid Capsule.Infection and immunity · 2016Article
- Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity.PLoS neglected tropical diseases · 2016Article
- Metatranscriptomics reveals metabolic adaptation and induction of virulence factors by Haemophilus parasuis during lung infection.Veterinary research · 2015Article
- Pasteurella multocida: from zoonosis to cellular microbiology.Clinical microbiology reviews · 2013Review
- Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.PLoS neglected tropical diseases · 2013Article
- Burkholderia pseudomallei transcriptional adaptation in macrophages.BMC genomics · 2012Article
- Selective Capture of Transcribed Sequences: A Promising Approach for Investigating Bacterium-Insect Interactions.Insects · 2012Review
- Article
- A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production.BMC genomics · 2010Article
- Microarray analysis of response of Salmonella during infection of HLA-B27- transfected human macrophage-like U937 cells.BMC genomics · 2010Article
- Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1.Microbiology (Reading, England) · 2010Article
- Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine.Infection and immunity · 2009Article
- Basic concepts of microarrays and potential applications in clinical microbiology.Clinical microbiology reviews · 2009Review
- The transcriptional response of Pasteurella multocida to three classes of antibiotics.BMC genomics · 2009Article
- Transcriptome changes in Mycoplasma hyopneumoniae during infection.Infection and immunity · 2008Article
- Decoration of Pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Little is known about the genomic-scale transcriptional responses of bacteria during natural infections. We used whole-genome microarray analysis to assess the transcriptional state of the gram-negative pathogen Pasteurella multocida, the causative agent of fowl cholera, during infection in the natural chicken host. We compared the expression profiles of bacteria harvested from the blood of septicemic chickens experiencing late-stage fowl cholera with those from bacteria grown in rich medium. Independent analysis of bacterial expression profiles from the infection of three individual chickens indicated that 40 genes were differentially expressed in all three individuals, 126 were differentially expressed in two of the three individuals, and another 372 were differentially expressed in one individual. Real-time reverse transcription-PCR assays were used to confirm the expression ratios for a number of genes. Of the 40 genes differentially expressed in all three individuals, 17 were up-regulated and 23 were down-regulated in the host compared with those grown in rich medium. The majority (10 of 17) of the up-regulated genes were involved in amino acid transport and metabolism and energy production and conversion, clearly indicating how P. multocida alters its biosynthetic and energy production pathways to cope with the host environment. In contrast, the majority (15 of 23) of down-regulated genes were of unknown or poorly characterized functions. There were clear differences in gene expression between the bacteria isolated from each of the three chickens, a finding consistent with individual host variation being an important factor in determining pathogen gene expression. Interestingly, bacteria from only two of the three infected animals had a gene expression profile highly similar to that observed during growth under iron-limiting conditions, suggesting that severe iron starvation may not always occur during P. multocida infection.
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