ArticleInfection and immunity2002
Molecular characterization of a serotype O121:H19 clone, a distinct Shiga toxin-producing clone of pathogenic Escherichia coli.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 92 citations in OpenAlex.
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- Overview of pathogenic Escherichia coli, with a focus on Shiga toxin-producing serotypes, global outbreaks (1982-2024) and food safety criteria.Gut pathogens · 2024Review
- The "Big Six": Hidden Emerging Foodborne Bacterial Pathogens.Tropical medicine and infectious disease · 2022Review
- Comparative genomic and phenotypic analyses of the virulence potential in Shiga toxin-producingFrontiers in cellular and infection microbiology · 2022Article
- Analysis of Wastewater Reveals the Spread of Diverse Extended-Spectrum β-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- High Prevalence of Virulence Genes in Specific Genotypes of Atypical EnteropathogenicFrontiers in cellular and infection microbiology · 2017Article
- Development of a High Resolution Virulence Allelic Profiling (HReVAP) Approach Based on the Accessory Genome of Escherichia coli to Characterize Shiga-Toxin Producing E. coli (STEC).Frontiers in microbiology · 2016Article
- Genetic Diversity of the fliC Genes Encoding the Flagellar Antigen H19 of Escherichia coli and Application to the Specific Identification of Enterohemorrhagic E. coli O121:H19.Applied and environmental microbiology · 2015Article
- Genomic diversity and virulence profiles of historical Escherichia coli O157 strains isolated from clinical and environmental sources.Applied and environmental microbiology · 2015Article
- Characterization of Shiga-toxigenic Escherichia coli isolated from cases of diarrhoea & haemolytic uremic syndrome in north India.The Indian journal of medical research · 2014Article
- Detection of diarrhoeagenic Escherichia coli in clinical and environmental water sources in South Africa using single-step 11-gene m-PCR.World journal of microbiology & biotechnology · 2014Article
- Characterization of Shiga toxin-producing Escherichia coli isolated from healthy pigs in China.BMC microbiology · 2014Article
- Shiga toxin-producing Escherichia coli in yaks (Bos grunniens) from the Qinghai-Tibetan Plateau, China.PloS one · 2013Article
- Serotypes and virulence profiles of non-O157 Shiga toxin-producing Escherichia coli isolates from bovine farms.Applied and environmental microbiology · 2011Article
- OI-57, a genomic island of Escherichia coli O157, is present in other seropathotypes of Shiga toxin-producing E. coli associated with severe human disease.Infection and immunity · 2010Article
- Cryptic lineages of the genus Escherichia.Applied and environmental microbiology · 2009Article
- Article
- The expression of plasmid mediated afimbrial adhesin genes in an avian septicemic Escherichia coli strain.Journal of veterinary science · 2008Article
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7 authors at 3 institutions in 1 country.
Funding
Abstract
Most illnesses caused by Shiga toxin-producing Escherichia coli (STEC) have been attributed to E. coli serotype O157:H7, but non-O157 STEC infections are now increasingly recognized as public health problems worldwide. The O121:H19 serotype is being isolated more frequently from clinical specimens and has been implicated in one waterborne outbreak. We used multilocus virulence gene profiling, a PCR-based assay, to characterize the virulence gene content of 24 isolates of serotype O121:H19 and nonmotile variants. We also performed multilocus enzyme electrophoresis and multilocus sequencing to establish the clonal relatedness of O121 isolates and to elucidate the relationship of O121 to common STEC clones. The 24 isolates were found to represent a single bacterial clone, as there was no allelic variation across 18 enzyme loci among the isolates. The complete nucleotide sequence of the intimin gene differed by four substitutions from that of the epsilon (Int- epsilon ) allele of O103:H2 strain PMK5. The typical O121 virulence gene profile was similar to the profiles of enterohemorrhagic E. coli (EHEC) clones of E. coli: it included a Shiga toxin 2 gene (stx(2)), two genes on the EHEC plasmid (toxB and ehxA), and the gene encoding intimin (eae). Despite the similarities, putative virulence genes distributed on O islands-large chromosomal DNA segments present in the O157:H7 genome-were useful for discriminating among STEC serotypes and the O121:H19 clone had a composite profile that was distinct from the profiles of the other major EHEC clones of pathogenic E. coli. On the basis of sequencing analysis with 13 housekeeping genes, the O121:H19 clone did not fall into any of the four classical EHEC and enteropathogenic E. coli groups but instead was closely related to two eae-negative STEC strains.
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