Evidence map›Paper›PMID 12436425›Full record

ReviewJournal of neurobiology2002

Nicotinic receptor-mediated effects on appetite and food intake.

Young-Hwan Jo, David A Talmage, Lorna W Role

Abstract readReview
In one paragraph

Review in Journal of neurobiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 4 syntheses or guidelines pooled it, 323 citations in OpenAlex.

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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Young-Hwan JoDepartment of Anatomy and Cell Biology, in the Center for Neurobiology and Behavior, Columbia, University, New York, NY 10032, USA.
David A Talmage
Lorna W Role
Columbia University · US

Funding

MODULATORY EFFECTS OF SUBSTANCE P ON AUTONOMIC NEURONSR01NS022061 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI PLOTKIN, JOSHUA L · 1985 to 2019
$9.6M
EXPRESSION OF NEURONAL NICOTINIC ACETYLOCHOLINE RECEPTORR01NS029071 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ROLE, LORNA W · 1991 to 2009
$3.6M
MECHANISM OF ANTIONCOGENIC ACTION OF RETINOIDSR01CA079737 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TALMAGE, DAVID A · 1999 to 2003
$1.0M
NCI NIH HHS CA79737NINDS NIH HHS NS22061NINDS NIH HHS NS29071NINDS NIH HHS R01 NS022061NINDS NIH HHS R01 NS029071
6 · The paper itself

Abstract

It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite-suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non-neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus.

Indexed as

AnimalsAppetite RegulationEatingHumansHypothalamusNicotineReceptors, NicotinicSmokingNicotineReceptors, Nicotinic

Identifiers

PMID12436425
PMCPMC2367209
OpenAlexW2059698784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.