ReviewAntimicrobial agents and chemotherapy2002
Genes involved in bacitracin resistance in Streptococcus mutans.
Review in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 93 citations in OpenAlex.
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- Guarding the walls: the multifaceted roles of Bce modules in cell envelope stress sensing and antimicrobial resistance.Journal of bacteriology · 2024Review
- Effect of glycerol on properties of chitosan/chlorhexidine membranes and antibacterial activity againstFrontiers in microbiology · 2024Article
- Gene Rearrangement and Modification of Immunity Factors Are Correlated with the Insertion of Bacteriocin Cassettes in Streptococcus mutans.Microbiology spectrum · 2022Article
- Effects of pH on the Properties of Membrane Vesicles Including Glucosyltransferase inMicroorganisms · 2021Article
- Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms.PLoS genetics · 2021Article
- Article
- Potential Risk of Spreading Resistance Genes within Extracellular-DNA-Dependent Biofilms of Streptococcus mutans in Response to Cell Envelope Stress Induced by Sub-MICs of Bacitracin.Applied and environmental microbiology · 2020Article
- Resistance Mechanisms to Antimicrobial Peptides in Gram-Positive Bacteria.Frontiers in microbiology · 2020Review
- Bacitracin resistance and enhanced virulence of Streptococcus suis via a novel efflux pump.BMC veterinary research · 2019Article
- Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides.Nature chemical biology · 2019Article
- Role of Two-Component System Response RegulatorFrontiers in microbiology · 2019Article
- Complete genome of streamlined marine actinobacterium Pontimonas salivibrio strain CL-TW6BMC genomics · 2018Article
- Vitamin D Compounds Are Bactericidal against Streptococcus mutans and Target the Bacitracin-Associated Efflux System.Antimicrobial agents and chemotherapy · 2018Article
- Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective.Frontiers in microbiology · 2018Review
- RgpF Is Required for Maintenance of Stress Tolerance and Virulence in Streptococcus mutans.Journal of bacteriology · 2017Article
- The Two-Component System ChtRS Contributes to Chlorhexidine Tolerance in Enterococcus faecium.Antimicrobial agents and chemotherapy · 2017Article
- Bacterial Evasion of Host Antimicrobial Peptide Defenses.Microbiology spectrum · 2016Review
- Functional analysis of a bacitracin resistance determinant located on ICECp1, a novel Tn916-like element from a conjugative plasmid in Clostridium perfringens.Antimicrobial agents and chemotherapy · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mutans is resistant to bacitracin, which is a peptide antibiotic produced by certain species of Bacillus. The purpose of this study was to clarify the bacitracin resistance mechanism of S. mutans. We cloned and sequenced two S. mutans loci that are involved in bacitracin resistance. The rgp locus, which is located downstream from rmlD, contains six rgp genes (rgpA to rgpF) that are involved in rhamnose-glucose polysaccharide (RGP) synthesis in S. mutans. The inactivation of RGP synthesis in S. mutans resulted in an approximately fivefold-higher sensitivity to bacitracin relative to that observed for the wild-type strain Xc. The second bacitracin resistance locus comprised four mbr genes (mbrA, mbrB, mbrC, and mbrD) and was located immediately downstream from gtfC, which encodes the water-insoluble glucan-synthesizing enzyme. Although the bacitracin sensitivities of mutants that had defects in flanking genes were similar to that of the parental strain Xc, mutants that were defective in mbrA, mbrB, mbrC, or mbrD were about 100 to 120 times more sensitive to bacitracin than strain Xc. In addition, a mutant that was defective in all of the mbrABCD genes and rgpA was more sensitive to bacitracin than either the RGP or Mbr mutants. We conclude that RGP synthesis is related to bacitracin resistance in S. mutans and that the mbr genes modulate resistance to bacitracin via an unknown mechanism that is independent of RGP synthesis.
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