ArticleProceedings of the National Academy of Sciences of the United States of America2002
Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05174104 (Impact of Vestibular Rehabilitation on Metabolic Aspects and Chronobiological Behavior), which is not on this map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Vestibular Rehabilitation on Metabolic Aspects and Chronobiological Behavior
Who cites it
46 citing papers in PubMed, 110 citations in OpenAlex.
- Non-invasive vestibular nerve stimulation (VeNS) reduces visceral adipose tissue: results of a randomised controlled trial.Scientific reports · 2025Trial
- Entrainment of the human circadian pacemaker to longer-than-24-h days.Proceedings of the National Academy of Sciences of the United States of America · 2007Trial
- Prevalence and direct costs of vestibular disease in France - matched case-control study results from the 2022 and 2023 french health data system.Cost effectiveness and resource allocation : C/E · 2026Article
- Earth Vertical Motions Disrupt Sleep and Next Day Performance.Nature and science of sleep · 2026Article
- Hypergravity, Microgravity, and Animal Research.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Altered Body Composition in Dizziness and Vestibular Dysfunction: Insights From the Korean National Health and Nutrition Examination Survey.Journal of Korean medical science · 2025Article
- The vestibular system in pain and embodiment: cortical overlap, modulatory potential, and therapeutic perspectives.Frontiers in neuroscience · 2025Article
- Hypergravity stimulates mechanical behavior and micro-architecture of tibia in rats.Journal of bone and mineral metabolism · 2024Article
- Article
- Vestibular CCK signaling drives motion sickness-like behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Chronic Vestibular Hypofunction Is Associated with Impaired Sleep: Results from the DizzyReg Patient Registry.Journal of clinical medicine · 2023Article
- Tackling Insomnia Symptoms through Vestibular Stimulation in Patients with Breast Cancer: A Perspective Paper.Cancers · 2023Article
- Article
- Vestibular Disorders and Hormonal Dysregulations: State of the Art and Clinical Perspectives.Cells · 2023Review
- Hypergravity load-induced hyperglycemia occurs due to hypothermia and increased plasma corticosterone level in mice.The journal of physiological sciences : JPS · 2022Article
- Hormones and Vestibular Disorders: The Quest for Biomarkers.Brain sciences · 2022Article
- Whole-brain monosynaptic outputs and presynaptic inputs of GABAergic neurons in the vestibular nuclei complex of mice.Frontiers in neuroscience · 2022Article
- Effects of Vestibular Damage on the Sleep and Expression Level of Orexin in the Hypothalamus of Rats and Its Correlation with Autophagy and Akt Tumor Signal Pathway.Journal of oncology · 2022Article
- The application of artificial gravity in medicine and space.Frontiers in physiology · 2022Review
- Changes in body composition in unilateral vestibular hypofunction: relationships between bioelectrical impedance analysis and neuro-otological parameters.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic exposure to increased force environments (+G) has pronounced effects on the circadian and homeostatic regulation of body temperature (T(b)), ambulatory activity (Act), heart rate, feeding, and adiposity. By using the Brn 3.1 knockout mouse, which lacks vestibular hair cells, we recently described a major role of the vestibular system in mediating some of these adaptive responses. The present study used the C57BL6JEi-het mouse strain (het), which lacks macular otoconia, to elucidate the contribution of specific vestibular receptors. In this study, eight het and eight WT mice were exposed to 2G for 8 weeks by means of chronic centrifugation. In addition, eight het and eight WT mice were maintained as 1G controls in similar conditions. Upon 2G exposure, the WT exhibited a decrease in T(b) and an attenuated T(b) circadian rhythm. Act means and rhythms also were attenuated. Body mass and food intake were significantly lower than the 1G controls. After 8 weeks, percent body fat was significantly lower in the WT mice (P < 0.0001). In contrast, the het mice did not exhibit a decrease in mean T(b) and only a slight decrease in T(b) circadian amplitude. het Act levels were attenuated similarly to the WT mice. Body mass and food intake were only slightly attenuated in the het mice, and percent body fat, after 8 weeks, was not different in the 2G het group. These results link the vestibular macular receptors with specific alterations in homeostatic and circadian regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.