ArticleNucleic acids research2002
Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 126 citations in OpenAlex.
- Strategies for HIV-1 suppression through key genes and cell therapy.Frontiers in medicine · 2023Review
- Editing out HIV: application of gene editing technology to achieve functional cure.Retrovirology · 2021Review
- DisCoVering potential candidates of RNAi-based therapy for COVID-19 using computational methods.PeerJ · 2021Article
- Tapping the RNA world for therapeutics.Nature structural & molecular biology · 2018Review
- Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide.Molecular therapy. Nucleic acids · 2017Article
- An in silico approach to design potential siRNA molecules for ICP22 (US1) gene silencing of different strains of human herpes simplex 1.Journal of young pharmacists : JYP · 2013Article
- Design of potential siRNA molecules for T antigen gene silencing of Merkel Cell Polyomavirus.Bioinformation · 2012Article
- Design of potential siRNA molecules for hepatitis delta virus gene silencing.Bioinformation · 2012Article
- Silencing of HTLV-1 gag and env genes by small interfering RNAs in HEK 293 cells.Journal of virological methods · 2011Article
- Application of RNA interference in treating human diseases.Journal of genetics · 2010Review
- Lipid-based systemic delivery of siRNA.Advanced drug delivery reviews · 2009Review
- Progress in the therapeutic applications of siRNAs against HIV-1.Methods in molecular biology (Clifton, N.J.) · 2009Review
- Inhibition of foot-and-mouth disease virus replication in vitro and in vivo by small interfering RNA.Virology journal · 2008Article
- The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA.PloS one · 2008Article
- RNA interference: an emerging generation of biologicals.Biotechnology journal · 2008Review
- RNA interference and antiviral therapy.World journal of gastroenterology · 2007Review
- RNAi therapeutics: principles, prospects and challenges.Advanced drug delivery reviews · 2007Review
- Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome.Retrovirology · 2007Article
- Inhibition of hepatitis B virus expression and replication by RNA interference in HepG2.2.15.World journal of gastroenterology · 2006Article
- Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA.Gene therapy · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RNA interference (RNAi) phenomenon is a recently observed process in which the introduction of a double-stranded RNA (dsRNA) into a cell causes the specific degradation of a mRNA containing the same sequence. The 21-23 nt guide RNAs, generated by RNase III cleavage from longer dsRNAs, are associated with sequence-specific mRNA degradation. Here, we show that dsRNA specifically suppresses the expression of HIV-1 genes. To study dsRNA-mediated gene interference in HIV-1-infected cells, we have designed six long dsRNAs containing the HIV-1 gag and env genes. HIV-1 replication was totally suppressed in a sequence-specific manner by the dsRNAs in HIV-1-infected cells. Especially, E2 dsRNA containing the major CD4-binding domain sequence of gp120, as the target of the HIV-1 env gene, dramatically inhibited the expression of the HIV-1 p24 antigen in PBMCs for a relatively long time. The dsRNA interference method seems to be a promising new strategy for anti-HIV-1 gene therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.