ArticleThe Journal of physiology2002
Upregulation of proinflammatory cytokines and nerve growth factor by intraplantar injection of capsaicin in rats.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Dietary Patterns Associated With Heat Retention in Blood Vessel Syndrome (HRBVS) in Coronary Heart Disease: A Cross-Sectional Study.International journal of general medicine · 2025Article
- Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli.Bioengineering & translational medicine · 2023Article
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- Effect of denervation on burn wound healing.Annals of burns and fire disasters · 2018Article
- Fundamental pharmacological expressions on ocular exposure to capsaicin, the principal constituent in pepper sprays.Scientific reports · 2018Article
- Preclinical Assessment of Inflammatory Pain.CNS neuroscience & therapeutics · 2016Review
- Calcitonin gene-related peptide: physiology and pathophysiology.Physiological reviews · 2014Review
- Impact of subcutaneous infiltration of 0.5% bupivacaine on post-operative C-reactive protein serum titer after craniotomy surgery.Medical journal of the Islamic Republic of Iran · 2013Article
- Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome.Molecular pain · 2012Article
- Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain.Journal of neuroinflammation · 2012Article
- Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain.Brain research · 2011Article
- Growth factors and neuropathic pain.Current pain and headache reports · 2011Review
- Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons.Neuroscience · 2010Article
- Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation.Neuroscience · 2010Article
- Antimicrobial anxiety: the impact of stress on antimicrobial immunity.Journal of leukocyte biology · 2010Review
- Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome.European journal of pain (London, England) · 2009Article
- Article
- Blood protein reactions to ablation of capsaicin-sensitive neurons.Neuroscience and behavioral physiology · 2006Article
- Without nerves, immunology remains incomplete -in vivo veritas.Immunology · 2005Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsaicin-sensitive primary afferents (CSPA) are known to be involved in nociception and neurogenic inflammation. Extensive research has been devoted to the sensory role of these fibres but less attention has been paid to their local effector function. This study aimed at gaining more insight into the molecular mechanisms underlying the neurogenic inflammation induced by this special group of afferent fibres. Different groups of rats (n = 5 in each group), either naive or subjected to selective ablation of their CSPA, received individual intraplantar injections of saline, capsaicin, its vehicle or capsaicin preceded by its antagonist, capsazepine. Acute tests for nociception were used to assess the variations of the nociceptive thresholds. Variations of the levels of proinflammatory cytokines and nerve growth factor (NGF) were measured by enzyme-linked immunosorbent assay (ELISA). Intraplantar injection of capsaicin (10 microg in 50 microl) produced a sustained thermal and mechanical hyperalgesia that peaked at 3-6 h and disappeared 24 h following the injection. Similar capsaicin injection in further groups of rats produced an early upregulation of the proinflammatory cytokines and NGF, which peaked at 30-60 min and returned to control levels within 2-5 h. Similar effects were observed following the application of either capsaicin or intense electrical stimulation on the cut end of the distal portion of the sciatic nerve. The effects of capsaicin were abolished in rats subjected to selective ablation of their CSPA. These results demonstrate that CSPA can simultaneously challenge the immune system through the release of proinflammatory mediators and the central nervous system through nociceptive signalling and can therefore serve as a common afferent pathway to both immune and nervous systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.