ArticleThe Journal of physiology2002
Control of intracellular chloride concentration and GABA response polarity in rat retinal ON bipolar cells.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
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- Three-Day Continuous Oxytocin Infusion Attenuates Thermal and Mechanical Nociception by Rescuing Neuronal Chloride HomeostasisFrontiers in pharmacology · 2022Article
- Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.Nature communications · 2021Article
- Dopamine Regulation of GABACurrent biology : CB · 2017Article
- MeCP2 Binding Cooperativity Inhibits DNA Modification-Specific Recognition.Biochemistry · 2016Article
- Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.The Journal of general physiology · 2015Article
- Differential encoding of spatial information among retinal on cone bipolar cells.Journal of neurophysiology · 2015Article
- Seasonal induction of GABAergic excitation in the central mammalian clock.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Synaptic remodeling generates synchronous oscillations in the degenerated outer mouse retina.Frontiers in neural circuits · 2014Article
- Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.Journal of neurophysiology · 2013Article
- Inhibitory mechanisms that generate centre and surround properties in ON and OFF brisk-sustained ganglion cells in the rabbit retina.The Journal of physiology · 2013Article
- Lateral interactions in the outer retina.Progress in retinal and eye research · 2012Review
- Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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- Emerging role of WNK1 in pathologic central nervous system signaling.Annals of neurosciences · 2011Review
- Rebound discharge in deep cerebellar nuclear neurons in vitro.Cerebellum (London, England) · 2010Review
- Guinea pig horizontal cells express GABA, the GABA-synthesizing enzyme GAD 65, and the GABA vesicular transporter.The Journal of comparative neurology · 2010Article
- Retinal synaptic pathways underlying the response of the rabbit local edge detector.Journal of neurophysiology · 2010Article
- Immunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells.The European journal of neuroscience · 2010Article
- GABAa and GABAc receptor-mediated modulation of responses to color stimuli: electroretinographic study in the turtle Emys orbicularis.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABAergic modulation of retinal bipolar cells plays a crucial role in early visual processing. It helps to form centre-surround receptive fields which filter the visual signal spatially at the bipolar cell dendrites in the outer retina, and it produces temporal filtering at the bipolar cell synaptic terminals in the inner retina. The observed chloride transporter distribution in ON bipolar cells has been predicted to produce an intracellular chloride concentration, [Cl(-)](i), that is significantly higher in the dendrites than in the synaptic terminals. This would allow dendritic GABA-gated Cl(-) channels to generate the depolarization needed for forming the lateral inhibitory surround of the cell's receptive field, while synaptic terminal GABA-gated Cl(-) channels generate the hyperpolarization needed for temporal shaping of the light response. In contrast to this idea, we show here that in ON bipolar cells [Cl(-)](i) is only slightly higher in the dendrites than in the synaptic terminals, and that GABA-gated channels in the dendrites may generate a hyperpolarization rather than a depolarization. We also show that [Cl(-)](i) is controlled by movement of Cl(-) through ion channels in addition to transporters, that changes of [K(+)](o) alter [Cl(-)](i) and that voltage-dependent equilibration of [Cl(-)](i) in bipolar cells will produce a time-dependent adaptation of GABAergic modulation with a time constant of 8 s after illumination-evoked changes of membrane potential. Time-dependent adaptation of [Cl(-)](i) to voltage changes in retinal bipolar cells may add a previously unsuspected layer of temporal processing to signals as they pass through the retina.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.