ArticleAmerican journal of human genetics2002
Male mouse recombination maps for each autosome identified by chromosome painting.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
104 citing papers in PubMed, 201 citations in OpenAlex.
- Molecular assessment of recombination processing across genetically diverse mouse strains reveals sexually dimorphic determinants of crossover distribution beyond chromosome length.Molecular biology and evolution · 2026Article
- Orchestrating homolog segregation in meiosis I: molecular logic and regulatory networks with emphasis on male metaphase I.Cell communication and signaling : CCS · 2026Review
- Chromosome length is not the sole determinant of sexually dimorphic crossover rates during mammalian meiosis: Insights from genetically diverse mouse strains.bioRxiv : the preprint server for biology · 2025Article
- Interference length reveals regularity of crossover placement across species.Nature communications · 2024Article
- Mapping crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq.Cell discovery · 2024Article
- Predicting recombination frequency from map distance.Heredity · 2023Article
- Dissecting the Meiotic Recombination Patterns in aInternational journal of molecular sciences · 2023Article
- Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images.Frontiers in cell and developmental biology · 2023Article
- TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse.Scientific reports · 2022Article
- Article
- The impact of chromosomal fusions on 3D genome folding and recombination in the germ line.Nature communications · 2021Article
- DNA Organization along Pachytene Chromosome Axes and Its Relationship with Crossover Frequencies.International journal of molecular sciences · 2021Article
- Meiotic Crossover Patterning.Frontiers in cell and developmental biology · 2021Review
- Therapeutic Dose of Hydroxyurea-Induced Synaptic Abnormalities on the Mouse Spermatocyte.Frontiers in physiology · 2021Article
- Meiosis reveals the early steps in the evolution of a neo-XY sex chromosome pair in the African pygmy mouse Mus minutoides.PLoS genetics · 2020Article
- A novel function for CDK2 activity at meiotic crossover sites.PLoS biology · 2020Article
- The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.Molecular cell · 2020Article
- MLH1 focus mapping in the guinea fowl (Numida meleagris) give insights into the crossover landscapes in birds.PloS one · 2020Article
- High-Throughput Single-Cell Sequencing with Linear Amplification.Molecular cell · 2019Article
- Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish.Genome biology and evolution · 2019Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Linkage maps constructed from genetic analysis of gene order and crossover frequency provide few clues to the basis of genomewide distribution of meiotic recombination, such as chromosome structure, that influences meiotic recombination. To bridge this gap, we have generated the first cytological recombination map that identifies individual autosomes in the male mouse. We prepared meiotic chromosome (synaptonemal complex [SC]) spreads from 110 mouse spermatocytes, identified each autosome by multicolor fluorescence in situ hybridization of chromosome-specific DNA libraries, and mapped >2,000 sites of recombination along individual autosomes, using immunolocalization of MLH1, a mismatch repair protein that marks crossover sites. We show that SC length is strongly correlated with crossover frequency and distribution. Although the length of most SCs corresponds to that predicted from their mitotic chromosome length rank, several SCs are longer or shorter than expected, with corresponding increases and decreases in MLH1 frequency. Although all bivalents share certain general recombination features, such as few crossovers near the centromeres and a high rate of distal recombination, individual bivalents have unique patterns of crossover distribution along their length. In addition to SC length, other, as-yet-unidentified, factors influence crossover distribution leading to hot regions on individual chromosomes, with recombination frequencies as much as six times higher than average, as well as cold spots with no recombination. By reprobing the SC spreads with genetically mapped BACs, we demonstrate a robust strategy for integrating genetic linkage and physical contig maps with mitotic and meiotic chromosome structure.
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