ArticleBritish journal of pharmacology2002
Pacific ciguatoxin-1b effect over Na+ and K+ currents, inositol 1,4,5-triphosphate content and intracellular Ca2+ signals in cultured rat myotubes.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Recent Advances in the Detection of Food Toxins Using Mass Spectrometry.Chemical research in toxicology · 2023Review
- In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity.Archives of toxicology · 2022Article
- Review
- Gambierol Blocks a KToxins · 2022Article
- Current Trends and New Challenges in Marine Phycotoxins.Marine drugs · 2022Review
- Sulfo-Gambierones, Two New Analogs of Gambierone Produced byMarine drugs · 2021Article
- Article
- Article
- Article
- Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis.Cells · 2020Review
- Pacific Ciguatoxin Induces Excitotoxicity and Neurodegeneration in the Motor Cortex Via Caspase 3 Activation: Implication for Irreversible Motor Deficit.Molecular neurobiology · 2018Article
- Article
- Ladder-Shaped Ion Channel Ligands: Current State of Knowledge.Marine drugs · 2017Review
- Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.Neuropharmacology · 2016Article
- Marine Biotoxins: Occurrence, Toxicity, Regulatory Limits and Reference Methods.Frontiers in microbiology · 2016Review
- The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.The Journal of general physiology · 2013Article
- Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe.Marine drugs · 2010Review
- Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells.PloS one · 2008Article
- A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage-dependent sodium channels.British journal of pharmacology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The action of the main ciguatoxin involved in ciguatera fish poisoning in the Pacific region (P-CTX-1b) was studied in myotubes originated from rat skeletal muscle cells kept in primary culture. 2. The effect of P-CTX-1b on sodium currents at short times of exposure (up to 1 min) showed a moderate increase in peak Na+ current. During prolonged exposures, P-CTX-1b decreased the peak Na+ current. This action was always accompanied by an increase of leakage currents, tail currents and outward Na+ currents, resulting in an intracellular Na+ accumulation. This effect is blocked by prior exposure to tetrodotoxin (TTX) and becomes evident only after washout of TTX. 3. Low to moderate concentrations of P-CTX-1b (2-5 nM) partially blocked potassium currents in a manner that was dependent on the membrane potential. 4. P-CTX-1b (2-12 nM) caused a small membrane depolarization (3-5 mV) and an increase in the frequency of spontaneous action potential discharges that reached in general low frequencies (0.1-0.5 Hz). 5. P-CTX-1b (10 nM) caused a transient increase of intracellular inositol 1,4,5-trisphosphate (IP(3)) mass levels, which was blocked by TTX. 6. In the presence of P-CTX-1b (10 nM) and in the absence of external Ca2+, the intracellular Ca2+ levels show a transient increase in the cytoplasm as well as in the nuclei. The time course of this effect may reflect the action of IP(3) over internal stores activated by P-CTX-1b-induced membrane depolarization.
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