Evidence map›Paper›PMID 12429065›Full record

ReviewGenome biology2002

Finding signals that regulate alternative splicing in the post-genomic era.

Andrea N Ladd, Thomas A Cooper

Open access · bronzeAbstract readReview
In one paragraph

Review in Genome biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 223 citations in OpenAlex.

  1. Trial
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  5. RNA metabolism and links to inflammatory regulation and disease.Cellular and molecular life sciences : CMLS · 2021
    Review
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrea N LaddDepartment of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. tcooper@bcm.tmc.edu
Thomas A Cooper
Baylor College of Medicine · US

Funding

MOLECULAR PATHOGENESIS OF MYOTONIC DYSTROPHYR01AR045653 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 1999 to 2018
$8.3M
TROPONIN T ALTERNATIVE SPLICING IN EMBRYONIC HEARTR01HL045565 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 1996 to 2018
$5.5M
NHLBI NIH HHS R01 HL045565NHLBI NIH HHS R01HL45565NIAMS NIH HHS R01 AR045653NIAMS NIH HHS R01AR45653
6 · The paper itself

Abstract

Alternative splicing of pre-mRNAs is central to the generation of diversity from the relatively small number of genes in metazoan genomes. Auxiliary cis elements and trans-acting factors are required for the recognition of constitutive and alternatively spliced exons and their inclusion in pre-mRNA. Here, we discuss the regulatory elements that direct alternative splicing and how genome-wide analyses can aid in their identification.

Indexed as

Alternative SplicingAnimalsComputational BiologyEnhancer Elements, GeneticForecastingGene Expression RegulationGenomicsHumansRNA PrecursorsSignal TransductionTrans-ActivatorsRNA PrecursorsTrans-Activators

Identifiers

PMID12429065
PMCPMC244920
OpenAlexW1913751664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.