ReviewMolecular neurobiology
Intracellular A-beta amyloid, a sign for worse things to come?
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 75 citations in OpenAlex.
- Repeated Intra-cisterna Magna Injections with Amyloid-beta Oligomers to Induce Alzheimer's Disease in Cynomolgus Monkey (Experimental neurobiology · 2026Article
- Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction.Brain pathology (Zurich, Switzerland) · 2026Article
- Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases.Frontiers in neuroscience · 2023Review
- Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in AβAntioxidants (Basel, Switzerland) · 2020Article
- Amylin in Alzheimer's disease: Pathological peptide or potential treatment?Neuropharmacology · 2018Review
- Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane.Neurobiology of disease · 2018Article
- Effect of amyloids on the vesicular machinery: implications for somatic neurotransmission.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Pharmacokinetics of cotinine in rats: a potential therapeutic agent for disorders of cognitive function.Pharmacological reports : PR · 2015Article
- Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery.World journal of stem cells · 2013Article
- Characterizing affinity epitopes between prion protein and β-amyloid using an epitope mapping immunoassay.Experimental & molecular medicine · 2013Article
- Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.BMC neuroscience · 2013Article
- Article
- Aβ internalization by neurons and glia.International journal of Alzheimer's disease · 2011Article
- Fiber Tracts Anomalies in APPxPS1 Transgenic Mice Modeling Alzheimer's Disease.Journal of aging research · 2011Article
- Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.Acta neuropathologica · 2010Review
- HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons.PloS one · 2010Article
- The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases.Frontiers in psychiatry · 2010Article
- Increased accumulation of intraneuronal amyloid beta in HIV-infected patients.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Article
- Article
- Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility.Protein science : a publication of the Protein Society · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review the authors discuss the possible neuropathological role of intracellular amyloid-beta accumulation in Alzheimer's disease (AD) pathology. There is abundant evidence that at early stages of the disease, prior to A-beta amyloid plaque formation, A-beta peptides accumulate intraneuronally in the cerebral cortex and the hippocampus. The experimental evidence would indicate that intracellular amyloid-beta could originate both by intracellular biosynthesis and also from the uptake of amyloidogenic peptides from the extracellular milieu. Herein the aspects of the possible impact of intracellular amyloid-beta in human AD pathology are discussed, as well as recent observations from a rat transgenic model with a phenotype of intracellular accumulation of A-beta fragments in neurons of the hippocampus and cortex, without plaque formation. In this model, the intracellular amyloid-beta phenotype is accompanied by increased MAPK/ERK activity and tau hyperphosphorylation. Finally, the authors discuss the hypothesis that, prior to plaque formation, intracellular A-beta accumulation induces biochemical and pathological changes in the brain at the cellular level priming neurons to further cytotoxic attack of extracellular amyloidogenic peptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.